Evidence map›Paper›PMID 31570604›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The binuclear cluster of [FeFe] hydrogenase is formed with sulfur donated by cysteine of an [Fe(Cys)(CO)

Guodong Rao, Scott A Pattenaude, Katherine Alwan, Ninian J Blackburn, R David Britt, Thomas B Rauchfuss

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Biosynthesis of the Selenium-Substituted [FeFe]-Hydrogenases.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Characterization of Complex-B ([Fe(κJournal of the American Chemical Society · 2025
    Article
  4. A [FeFe] Hydrogenase-Rubrerythrin Chimeric Enzyme Functions to Couple HJournal of the American Chemical Society · 2025
    Article
  5. The activation of the metal-containing regulatory protein NiaR from Thermotoga maritima by its effector, nicotinic acid.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  6. Article
  7. Article
  8. Final Stages in the Biosynthesis of the [FeFe]-Hydrogenase Active Site.Angewandte Chemie (International ed. in English) · 2024
    Article
  9. Article
  10. A personal account on 25 years of scientific literature on [FeFe]-hydrogenase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Organometallic FeJournal of the American Chemical Society · 2022
    Article
  17. Biosynthesis of the [FeFe] hydrogenase H-clusterDalton transactions (Cambridge, England : 2003) · 2021
    Review
  18. HydG, the "dangler" iron, and catalytic production of free CO and CNDalton transactions (Cambridge, England : 2003) · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Guodong RaoDepartment of Chemistry, University of California, Davis, CA 95616.ORCID 0000-0001-8043-3436
Scott A PattenaudeSchool of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Katherine AlwanDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.
Ninian J BlackburnDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-9755-7838
R David BrittDepartment of Chemistry, University of California, Davis, CA 95616; rdbritt@ucdavis.edu rauchfuz@illinois.edu.ORCID 0000-0003-0889-8436
Thomas B RauchfussSchool of Chemical Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801; rdbritt@ucdavis.edu rauchfuz@illinois.edu.ORCID 0000-0003-2547-5128
Oregon Health & Science University · USUniversity of California, Davis · USUniversity of Illinois Urbana-Champaign · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
FE-S ENSEMBLES RELATED TO HYDROGENASE ACTIVITYR01GM061153 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI RAUCHFUSS, THOMAS · 2000 to 2025
$6.7M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Tracking Metal Flux Through a Pathogenic Export ComplexR01GM123725 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI BLACKBURN, NINIAN J · 2017 to 2020
$1.5M
NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM061153NIGMS NIH HHS R01 GM123725NIGMS NIH HHS R35 GM126961
6 · The paper itself

Abstract

The enzyme [FeFe]-hydrogenase (HydA1) contains a unique 6-iron cofactor, the H-cluster, that has unusual ligands to an Fe-Fe binuclear subcluster: CN

Indexed as

Bacterial ProteinsCatalysisCatalytic DomainCysteineElectron Spin Resonance SpectroscopyHydrogenaseIronOrganometallic CompoundsSulfurBacterial ProteinsCysteineHydrogenaseIronOrganometallic CompoundsSulfurcysteineH-cluster biosynthesisiron carbonyl cyanides

Identifiers

PMID31570604
PMCPMC6800375
OpenAlexW2978497242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.