ArticleProceedings of the National Academy of Sciences of the United States of America2019
An experimental test of the ovulatory homolog model of female orgasm.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Secondary Female Anorgasmia in Patients with Obsessive Traits: A Study.Behavioral sciences (Basel, Switzerland) · 2024Article
- The antidepressant fluoxetine (Prozac®) modulates estrogen signaling in the uterus and alters estrous cycles in mice.Molecular and cellular endocrinology · 2023Article
- The female orgasm and the homology concept in evolutionary biology.Journal of morphology · 2023Article
- Female Genital Variation Far Exceeds that of Male Genitalia: A Review of Comparative Anatomy of Clitoris and the Female Lower Reproductive Tract in Theria.Integrative and comparative biology · 2022Article
- Successful captive breeding of a Malayan pangolin population to the third filial generation.Communications biology · 2021Article
- Behavior is the ultimate arbiter: An alternative explanation for the inhibitory effect of fluoxetine on the ovulatory homolog model of orgasm in rabbits.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reply to Quintana et al.: Behavior is an unlikely mediator of fluoxetine effects on ovulation in rabbits.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- QnAs with Günter P. Wagner.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ovulatory homolog model of female orgasm posits that the neuro-endocrine mechanisms underlying female orgasm evolved from and are homologous to the mechanisms mediating copulation-induced ovulation in some mammals. This model predicts that pharmacological agents that affect human orgasm, such as fluoxetine, should also affect ovulation in animals with copulation-induced ovulation, such as rabbits. We tested this prediction by treating rabbits with daily doses of fluoxetine for 2 wk and found that fluoxetine treatment reduces the number of ovulations postcopulation by 30%. In a second experiment we tested whether this result was mediated by an effect on the brain or via peripheral serotonin functions. We treated animals with fluoxetine and induced ovulation with a single injection of human chorionic gonadotropin. In this experiment ovulation rate was nominally reduced by only 8%, which is statistically not significant. We conclude that the effect of fluoxetine on copulation-induced ovulation rate supports the ovulatory homolog model of female orgasm, suggesting that female orgasm has very deep evolutionary roots among the early eutherian mammals.
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