Evidence map›Paper›PMID 31570573›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Genetic ablation of purine salvage in

Mattie C Pawlowic, Mastanbabu Somepalli, Adam Sateriale, Gillian T Herbert, Alexis R Gibson, Gregory D Cuny, Lizbeth Hedstrom, Boris Striepen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Deciphering Transcription inbioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Genetic crosses within and between species ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Understanding theFrontiers in parasitology · 2024
    Review
  16. Current tropical medicine reports · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Mattie C PawlowicCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.ORCID 0000-0003-2002-6681
Mastanbabu SomepalliDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Adam SaterialeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gillian T HerbertCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602.
Alexis R GibsonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Gregory D CunyDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204.
Lizbeth HedstromDepartment of Biology, Brandeis University, Waltham, MA 02454.
Boris StriepenCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602; striepen@upenn.edu.
University of Georgia · USUniversity of Pennsylvania · USBrandeis University · USUniversity of Houston · US

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
PARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0M
Genetic Analysis of CryptosporidiumR01AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2014 to 2023
$4.2M
IMPDH inhibitors for the treatment of Cryptosporidium infectionsR01AI125362 · NIAID · UNIVERSITY OF HOUSTON · PI CUNY, GREGORY D · 2016 to 2020
$3.8M
Genetic Analysis of CryptosporidiumR37AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BORIS STRIEPEN · 2024 to 2026
$1.5M
Investigation of subtelomeric gene families in CryptosporidiumK99AI137442 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SATERIALE, ADAM · 2018 to 2019
$216k
Exploring TrpB in the pathogenesis of cryptosporidiosisF32AI124518 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SATERIALE, ADAM · 2016 to 2017
$107k
NIAID NIH HHS F32 AI124518NIAID NIH HHS K99 AI137442NIAID NIH HHS R01 AI112427NIAID NIH HHS R01 AI125362NIAID NIH HHS R37 AI112427NIAID NIH HHS T32 AI007532NIAID NIH HHS T32 AI060546Wellcome Trust 203134/Z/16/Z
6 · The paper itself

Abstract

The apicomplexan parasite

Indexed as

Biological TransportCell Line, TumorCryptosporidiosisCryptosporidium parvumHumansIMP DehydrogenaseMultienzyme ComplexesNucleotidesPurinesTetrahydrofolate DehydrogenaseThymidylate SynthaseIMP DehydrogenaseMultienzyme ComplexesNucleotidespurinePurinesTetrahydrofolate DehydrogenaseThymidylate Synthasethymidylate synthase-dihydrofolate reductaseCryptosporidiumdiarrheanucleotideparasitepurine

Identifiers

PMID31570573
PMCPMC6800313
OpenAlexW2977672125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.