ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Fine-Grained Mapping of Cortical Somatotopies in Chronic Complex Regional Pain Syndrome.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05696587 (Physical and Psychological Changes in Complex Regional Pain Syndrome), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical and Psychological Changes in Complex Regional Pain Syndrome (CRPS) Patients Undergoing Multimodal Rehabilitation
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Assessment of body perception disturbances in complex regional pain syndrome: A systematic review using the COSMIN guideline.European journal of pain (London, England) · 2022Pooled it
- Effects of mirror therapy in post-traumatic complex regional pain syndrome type-1: a randomized controlled study.Journal of rehabilitation medicine · 2024Trial
- Clinical and Molecular Barriers to Understanding the Pathogenesis, Diagnosis, and Treatment of Complex Regional Pain Syndrome (CRPS).International journal of molecular sciences · 2025Article
- Functional conductivity imaging: quantitative mapping of brain activity.Physical and engineering sciences in medicine · 2024Article
- Somatotopy of the sensory thalamus: inputs from directional deep brain stimulation in pain patients.Annals of clinical and translational neurology · 2024Article
- The role of torso stiffness and prediction in the biomechanics of anxiety: a narrative review.Frontiers in sports and active living · 2024Review
- Two-Dimensional Population Receptive Field Mapping of Human Primary Somatosensory Cortex.Brain topography · 2023Article
- Person-centred management of upper limb complex regional pain syndrome: an integrative review of non-pharmacological treatment.Hand therapy · 2023Review
- Body image and perception among adults with and without phantom limb pain.PM & R : the journal of injury, function, and rehabilitation · 2023Article
- Atypical influence of biomechanical knowledge in Complex Regional Pain Syndrome-towards a different perspective on body representation.Scientific reports · 2023Article
- VR for Pain Relief.Current topics in behavioral neurosciences · 2023Article
- Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia.Human brain mapping · 2022Article
- Clinical Manifestations of Body Memories: The Impact of Past Bodily Experiences on Mental Health.Brain sciences · 2022Article
- [Complex regional pain syndrome-An update].Schmerz (Berlin, Germany) · 2022Article
- Body Structural Description Impairment in Complex Regional Pain Syndrome Type I.Frontiers in psychology · 2022Article
- Altered bodily perceptions in chronic neuropathic pain conditions and implications for treatment using immersive virtual reality.Frontiers in human neuroscience · 2022Review
- Article
- [Complex regional pain syndrome-An update].Der Nervenarzt · 2021Article
- The iSTOPP study: Protocol for a proof-of-concept randomised clinical trial of sensory discrimination training in people with persistent neck pain.Contemporary clinical trials communications · 2021Article
- Impaired Performance in Mental Rotation of Hands and Feet and Its Association with Social Cognition in Patients with Complex Regional Pain Syndrome.Pain medicine (Malden, Mass.) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
It has long been thought that severe chronic pain conditions, such as complex regional pain syndrome (CRPS), are not only associated with, but even maintained by a reorganization of the somatotopic representation of the affected limb in primary somatosensory cortex (S1). This notion has driven treatments that aim to restore S1 representations in CRPS patients, such as sensory discrimination training and mirror therapy. However, this notion is based on both indirect and incomplete evidence obtained with imaging methods with low spatial resolution. Here, we used fMRI to characterize the S1 representation of the affected and unaffected hand in humans (of either sex) with unilateral CRPS. The cortical area, location, and geometry of the S1 representation of the CRPS hand were largely comparable with those of both the unaffected hand and healthy controls. We found no differential relation between affected versus unaffected hand map measures and clinical measures (pain severity, upper limb disability, disease duration). Thus, if any map reorganization occurs, it does not appear to be directly related to pain and disease severity. These findings compel us to reconsider the cortical mechanisms underlying CRPS and the rationale for interventions that aim to "restore" somatotopic representations to treat pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.