ArticleThe Journal of biological chemistry2019
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.
Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Identification of rectal mucosa-secreted proteins by enzyme-linked immunosorbent assay for the investigation of sexual assault cases with anal penetration.International journal of legal medicine · 2026Article
- Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review).Molecular medicine reports · 2026Review
- Advanced adhesion and targeting strategies to prolong gut residence time and improve eLBP efficacy in colonic diseases.Advanced drug delivery reviews · 2025Review
- Evolutionary Analysis of Gene-expression Localization in the Model Crustacean,bioRxiv : the preprint server for biology · 2025Article
- Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation.European journal of immunology · 2025Article
- Mucus and mucin: changes in the mucus barrier in disease states.Tissue barriers · 2025Review
- Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience.Discovery immunology · 2025Article
- Host-derived CEACAM-laden vesicles engage enterotoxigenicProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Host-derived CEACAM-laden vesicles engage enterotoxigenicbioRxiv : the preprint server for biology · 2024Article
- Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.eLife · 2024Article
- The biochemical effects of carotenoids in orange carrots on the colonic proteome in a mouse model of diet-induced obesity.Frontiers in nutrition · 2024Article
- The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.Life science alliance · 2023Article
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- Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons.Scientific reports · 2023Article
- Intestinal mucus components and secretion mechanisms: what we do and do not know.Experimental & molecular medicine · 2023Review
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- Mechanism of electroacupuncture and herb-partitioned moxibustion on ulcerative colitis animal model: A study based on proteomics.World journal of gastroenterology · 2022Article
- Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Calcium-activated chloride channel regulator 1 (CLCA1) is one of the major nonmucin proteins found in intestinal mucus. It is part of a larger family of CLCA proteins that share highly conserved features and domain architectures. The CLCA domain arrangement is similar to proteins belonging to the ADAM (a disintegrin and metalloproteinase) family, known to process extracellular matrix proteins. Therefore, CLCA1 is an interesting candidate in the search for proteases that process intestinal mucus. Here, we investigated CLCA1's biochemical properties both
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Registered trials
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