ArticleBiophysical journal2019
Hypocalcemia-Induced Slowing of Human Sinus Node Pacemaking.
Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Calcitriol supplementation before parathyroidectomy and calcium level after surgery in parathyroid adenoma patients: a randomized controlled trial.Journal of endocrinological investigation · 2023Trial
- Preoperative hypocalcemia predicts postoperative complications in older orthopedic patients: A multicenter cohort study.PloS one · 2026Article
- Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Article
- Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort.Journal of clinical medicine · 2024Article
- Characterization of the pace-and-drive capacity of the human sinoatrial node: A 3D in silico study.Biophysical journal · 2022Article
- Hypoglycaemia combined with mild hypokalaemia reduces the heart rate and causes abnormal pacemaker activity in a computational model of a human sinoatrial cell.Journal of the Royal Society, Interface · 2021Article
- Intracellular NaInternational journal of molecular sciences · 2021Article
- Effect of citric-acid dialysate on the QTC-interval.Scientific reports · 2021Article
- Quantification and classification of potassium and calcium disorders with the electrocardiogram: What do clinical studies, modeling, and reconstruction tell us?APL bioengineering · 2020Review
- Dialysis-Induced Cardiovascular and Multiorgan Morbidity.Kidney international reports · 2020Review
- Research Highlights: Biophysics of Calcium.Biophysical journal · 2020Article
- Wearable health devices and personal area networks: can they improve outcomes in haemodialysis patients?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
- The Heart by Numbers.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Each heartbeat is initiated by cyclic spontaneous depolarization of cardiomyocytes in the sinus node forming the primary natural pacemaker. In patients with end-stage renal disease undergoing hemodialysis, it was recently shown that the heart rate drops to very low values before they suffer from sudden cardiac death with an unexplained high incidence. We hypothesize that the electrolyte changes commonly occurring in these patients affect sinus node beating rate and could be responsible for severe bradycardia. To test this hypothesis, we extended the Fabbri et al. computational model of human sinus node cells to account for the dynamic intracellular balance of ion concentrations. Using this model, we systematically tested the effect of altered extracellular potassium, calcium, and sodium concentrations. Although sodium changes had negligible (0.15 bpm/mM) and potassium changes mild effects (8 bpm/mM), calcium changes markedly affected the beating rate (46 bpm/mM ionized calcium without autonomic control). This pronounced bradycardic effect of hypocalcemia was mediated primarily by I
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