Evidence map›Paper›PMID 31570097›Full record

ArticleBMC molecular biology2019

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression.

Fan Li, Yun Wang, Hui Yang, Yingying Xu, Xiaoyan Zhou, Xiao Zhang, Zhaohong Xie, Jianzhong Bi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fan LiDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Yun WangDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Hui YangDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Yingying XuDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Xiaoyan ZhouDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Xiao ZhangDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China.
Zhaohong XieDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China. xie_zhaohong@126.com.
Jianzhong BiDepartment of Neurology, The Second Hospital of Shandong University, Shandong University, 247 North Park Avenue, Jinan, 250033, China. bjz@sdu.edu.cn.
Second Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe BACE1 antisense transcript (BACE1-AS) is a conserved long noncoding RNA (lncRNA). The level of BACE1-AS is significantly increased and the level of the BACE1 mRNA is slightly increased in subjects with AD. BACE1-AS exerts a significant moderating effect on the expression of the BACE1 mRNA and promotes the formation of Aβ. After the administration of Aβ

resultsThe administration of Aβ

conclusionsThe mechanism by which exogenous Aβ

Indexed as

Amyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesBrainCell Line, TumorHumansMiceMice, Inbred C57BLPeptide FragmentsRNA, Long NoncodingRNA, MessengerAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Amyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1-AS long non-coding RNA, humanBACE1 protein, humanBace1 protein, mouselong non-coding RNA BACE1-AS, mousePeptide FragmentsRNA, Long NoncodingRNA, MessengerAlzheimer’s diseaseAβBACE1-ASlncRNA

Identifiers

PMID31570097
PMCPMC6771094
OpenAlexW2979218058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.