Evidence map›Paper›PMID 31570054›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2019

Establishing an Animal Model of Single-Sided Deafness in

Renee M Banakis Hartl, Nathaniel T Greene, Victor Benichoux, Anna Dondzillo, Andrew D Brown, Daniel J Tollin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Renee M Banakis HartlDepartment of Otolaryngology, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Nathaniel T GreeneDepartment of Otolaryngology, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Victor BenichouxDepartment of Neuroscience, Institut Pasteur, Paris, France.
Anna DondzilloDepartment of Otolaryngology, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Andrew D BrownDepartment of Physiology and Biophysics, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Daniel J TollinDepartment of Otolaryngology, School of Medicine, University of Colorado, Aurora, Colorado, USA.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USInstitut Pasteur · FR

Funding

Institutional Training in Otolaryngology ResearchT32DC012280 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Yuri Agrawal, Sue C. Kinnamon · 2013 to 2026
$3.4M
NIDCD NIH HHS T32 DC012280
6 · The paper itself

Abstract

objectives(1) To characterize changes in brainstem neural activity following unilateral deafening in an animal model. (2) To compare brainstem neural activity from unilaterally deafened animals with that of normal-hearing controls. STUDY

designProspective controlled animal study.

settingVivarium and animal research facilities. SUBJECTS AND

methodsThe effect of single-sided deafness on brainstem activity was studied in

resultsFour animals underwent chemical deafening, with 2 normal-hearing animals as controls. ABRs confirmed unilateral loss of auditory function. Deafened animals demonstrated symmetric local field potential responses that were distinctly different than the contralaterally dominated responses of the inferior colliculus seen in normal-hearing animals.

conclusionWe successfully developed a model for unilateral deafness to investigate effects of single-sided deafness on brainstem plasticity. This preliminary investigation serves as a foundation for more comprehensive studies that will include cochlear implantation and manipulation of binaural cues, as well as functional behavioral tests.

Indexed as

ChinchillaDisease Models, AnimalAnimalsBrain StemEvoked Potentials, Auditory, Brain StemHearing Loss, Unilateralbrainstem plasticitychinchillainferior colliculuslocal field potentialssingle-sided deafness

Identifiers

PMID31570054
PMCPMC6917427
OpenAlexW2979021514

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.