ReviewBioengineered2019
Bioengineering of anaerobic digestion for volatile fatty acids, hydrogen or methane production: A critical review.
Review in Bioengineered, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 545 citations in OpenAlex.
- Waste-Based Volatile Fatty Acids for Fuel and Chemical Production.ACS energy letters · 2026Review
- Targeting Microorganisms in Lignocellulosic Biomass to Produce Biogas and Ensure Sanitation and Hygiene.Microorganisms · 2026Review
- Indigenous microbiome as a key strategy for producing green chemicals.Frontiers in microbiology · 2026Article
- Article
- Volatile fatty acid selectivity during electrodialysis: effect of a competing counterion on volatile fatty acid transport mechanisms.Journal of membrane science · 2025Article
- In situ methane enrichment with vacuum application to produce biogas with higher methane content.Environmental science and pollution research international · 2025Article
- Enhancing Methane Production from Lignite via Pyrite-Electrochemical Coupling and Microbial Community Restructuring.ACS omega · 2025Article
- Feasibility of anaerobic co-digestion for biogas production from recycled paper industry sludge: optimization of mixing ratios and application in two-stage CSTR system design.Water science and technology : a journal of the International Association on Water Pollution Research · 2025Article
- Volatile fatty acids recovery from thermophilic acidogenic fermentation using hydrophobic deep eutectic solvents.Journal of biological engineering · 2025Article
- Up-flow anaerobic sludge blanket bioreactor for the production of carboxylates: effect of inocula on process performance and microbial communities.Bioresources and bioprocessing · 2025Article
- Enhancing synthetic vinasse treatment efficiency using an integrated UASB-Modified Bardenpho Process.Bioresources and bioprocessing · 2024Article
- ATP biosensor reveals microbial energetic dynamics and facilitates bioproduction.Nature communications · 2024Article
- Integrated Biorefinery for a Next-Generation Methanization Process Focusing on Volatile Fatty Acid Valorization: A Critical Review.Molecules (Basel, Switzerland) · 2024Review
- Physical and Chemical Characteristics of Droppings as Sensitive Markers of Chicken Health Status.Animals : an open access journal from MDPI · 2024Article
- Review
- Use of N-Methylmorpholine N-oxide (NMMO) pretreatment to enhance the bioconversion of lignocellulosic residues to methane.Biomass conversion and biorefinery · 2024Article
- Effect of decoupling hydraulic and solid retention times on carbohydrate-rich residue valorization into carboxylic acids.Scientific reports · 2023Article
- Approaches to mitigation of hydrogen sulfide during anaerobic digestion process - A review.Heliyon · 2023Review
- Different stages of microbial community during the anaerobic digestion of food waste.Journal of food science and technology · 2023Review
- Role of Polysaccharides from Marine Seaweed as Feed Additives for Methane Mitigation in Ruminants: A Critical Review.Polymers · 2023Review
Corrections and comments
- Retraction · 2026-01-19Compromised Peer Review · Investigation by Journal/Publisher ·
- Retracted
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaerobic digestion (AD) is a well-established technology used for producing biogas or biomethane alongside the slurry used as biofertilizer. However, using a variety of wastes and residuals as substrate and mixed cultures in the bioreactor makes AD as one of the most complicated biochemical processes employing hydrolytic, acidogenic, hydrogen-producing, acetate-forming bacteria as well as acetoclastic and hydrogenoclastic methanogens. Hydrogen and volatile fatty acids (VFAs) including acetic, propionic, isobutyric, butyric, isovaleric, valeric and caproic acid and other carboxylic acids such as succinic and lactic acids are formed as intermediate products. As these acids are important precursors for various industries as mixed or purified chemicals, the AD process can be bioengineered to produce VFAs alongside hydrogen and therefore biogas plants can become biorefineries. The current review paper provides the theory and means to produce and accumulate VFAs and hydrogen, inhibit their conversion to methane and to extract them as the final products. The effects of pretreatment, pH, temperature, hydraulic retention time (HRT), organic loading rate (OLR), chemical methane inhibitions, and heat shocking of the inoculum on VFAs accumulation, hydrogen production, VFAs composition, and the microbial community were discussed. Furthermore, this paper highlights the possible techniques for recovery of VFAs from the fermentation media in order to minimize product inhibition as well as to supply the carboxylates for downstream procedures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.