Polygenic Risk Scores in Schizophrenia: Ready for the Real World?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study.Schizophrenia bulletin · 2026
   Article
2. Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons.Translational psychiatry · 2025
   Article
3. Deep Clinical Phenotyping of Schizophrenia Spectrum Disorders Using Data-Driven Methods: Marching towards Precision Psychiatry.Journal of personalized medicine · 2023
   Article
4. Psychotic disorders as a framework for precision psychiatry.Nature reviews. Neurology · 2023
   Review
5. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population.Social psychiatry and psychiatric epidemiology · 2023
   Article
6. Transferability of the PRS estimates for height and BMI obtained from the European ethnic groups to the Western Russian populations.Frontiers in genetics · 2023
   Article
7. Polygenic risk scores: An overview from bench to bedside for personalised medicine.Frontiers in genetics · 2022
   Review
8. A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.Biological psychiatry · 2021
   Article
9. Neurodevelopmental Trajectories and Psychiatric Morbidity: Lessons Learned From the 22q11.2 Deletion Syndrome.Current psychiatry reports · 2021
   Review
10. Three models for the regulation of polygenic scores in reproduction.Journal of medical ethics · 2021
    Article

Corrections and comments

• Comment on
  Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems.2019

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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