ReviewMedicina (Kaunas, Lithuania)2019
Oral Food Challenge.
Review in Medicina (Kaunas, Lithuania), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Allergenicity Assessment of Plant-Derived Sweet Proteins-In Silico, In Vitro, In Vivo, and Clinical Approach: A Systematic Review.Molecules (Basel, Switzerland) · 2026Pooled it
- Comparative evaluation of seven severity grading systems in pediatric oral food challenges: Distinctions between anaphylactic and non-anaphylactic reactions.The World Allergy Organization journal · 2026Article
- The Basophil Activation Test in the Diagnosis of Cow's Milk Allergy in Children: A Narrative Review.Nutrients · 2026Review
- Review
- Predictive Value of Molecular Biomarkers for Oral Food Challenge Outcomes in Children with Hazelnut and Peanut Allergies.Nutrients · 2026Article
- Does Previous Anaphylaxis Determine Differences Between Patients Undergoing Oral Food Challenges to Cow's Milk and Hen's Egg?Nutrients · 2026Article
- Concordance between crude extract and component allergens in a multiple allergen simultaneous test: a large-scale retrospective analysis.British journal of biomedical science · 2026Article
- Cow's Milk Protein Allergy: ETAPA Survey on Pediatric Management and Tolerance Acquisition.Children (Basel, Switzerland) · 2025Article
- Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025Review
- Asthma and Multi-Food Allergy Are Risk Factors for Oral Food Challenge Failure-A Single-Center Experience.Nutrients · 2025Article
- Serum Diamine Oxidase Levels in Relation to Skin Prick Testing and Specific IgE in Adults with Self-Reported Food Allergy.Journal of clinical medicine · 2025Article
- The importance of molecular studies in the diagnosis and monitoring of IgE-mediated cow's milk protein allergy in children: a pilot study.Postepy dermatologii i alergologii · 2025Article
- Scientific developments in understanding food allergy prevention, diagnosis, and treatment.Frontiers in immunology · 2025Review
- Baked Egg Oral Immunotherapy: Current State in Pediatric Age.Nutrients · 2024Review
- Oral Food Challenge in Children with Tree Nut and Peanut Allergy: The Predictive Value of Diagnostic Tests.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Metabolomics in Children Cow's Milk Protein Allergy: Possible Contribution from a System Biology Approach?Children (Basel, Switzerland) · 2024Review
- The role of pediatricians in the diagnosis and management of IgE-mediated food allergy: a review.Frontiers in pediatrics · 2024Review
- Impacts of people at-risk of either cow milk allergies or lactose intolerance on their daily calcium intake and bone mineral density.Frontiers in nutrition · 2024Article
- Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis.Biomedicines · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral food challenge (OFC) is the gold standard for diagnosis of IgE-mediated and non-IgE mediated food allergy. It is usually conducted to make diagnosis, to monitor for resolution of a food allergy, or to identify the threshold of responsiveness. Clinical history and lab tests have poor diagnostic accuracy and they are not sufficient to make a strict diagnosis of food allergy. Higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Several cut-off values, to make a diagnosis of some food allergies (e.g., milk, egg, peanut, etc.) without performing an OFC, have been suggested, but their use is still debated. The oral food challenge should be carried out by experienced physicians in a proper environment equipped for emergency, in order to carefully assess symptoms and signs and correctly manage any possible allergic reaction. This review does not intend to analyse comprehensively all the issues related to the diagnosis of food allergies, but to summarize some practical information on the OFC procedure, as reported in a recent issue by The Expert Review of Food Allergy Committee of Italian Society of Pediatric Allergy and Immunology (SIAIP).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.