ArticleInternational journal of environmental research and public health2019
Short-Term Effects of Meteorological Factors and Air Pollutants on Hand, Foot and Mouth Disease among Children in Shenzhen, China, 2009-2017.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Association between ambient air pollution and risk of hand, foot, and mouth disease: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Historical evolution, research hotspots and emerging trends of pediatric hand, foot, and mouth disease: a bibliometric worldview since the 21st century.Frontiers in medicine · 2025Pooled it
- The Effect of High and Low Ambient Temperature on Infant Health: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The effect of daily mean temperature on hand, foot and mouth disease and the source of regional heterogeneity in Chongqing, China, 2010-2019.Environmental health and preventive medicine · 2022Pooled it
- Analysis on the characteristics of delayed EV71 vaccination among children in the birth cohort from 2017 to 2022.Human vaccines & immunotherapeutics · 2026Article
- Interactive and joint effects of multiple meteorological and air pollution exposures on hand, foot and mouth disease risk in western China: a time-series analysis.BMJ public health · 2026Article
- Epidemiological characteristics and influencing factors of hand, foot and mouth disease reinfection cases in a large district of southern China.Frontiers in public health · 2026Article
- Ambient air pollution and meteorological factors associated with hand, foot, and mouth disease risk in Shenzhen, China: a time-series study.Frontiers in public health · 2026Article
- Article
- Bayesian joint spatiotemporal modelling of primary infection and reinfection of HFMD at county level in Jiangsu, China, 2009-2023.BMC public health · 2025Article
- Hand, Foot, and Mouth Disease Risk Prediction in Southern China: Time Series Study Integrating Web-Based Search and Epidemiological Surveillance Data.JMIR infodemiology · 2025Article
- Seasonal and Meteorological Drivers of Hand, Foot, and Mouth Disease Outbreaks Using Data-Driven Machine Learning Models.Tropical medicine and infectious disease · 2025Article
- Air pollution's numerical, spatial, and temporal heterogeneous impacts on childhood hand, foot and mouth disease: a multi-model county-level study from China.BMC public health · 2024Article
- How multiple air pollutants affect hand, foot, and mouth disease incidence in children: assessing effect modification by geographical context in multicity of Sichuan, southwest China.BMC public health · 2024Article
- Article
- Evaluation of models for multi-step forecasting of hand, foot and mouth disease using multi-input multi-output: A case study of Chengdu, China.PLoS neglected tropical diseases · 2023Article
- Study of the influence of meteorological factors on HFMD and prediction based on the LSTM algorithm in Fuzhou, China.BMC infectious diseases · 2023Article
- Associations between ambient air pollutants and childhood hand, foot, and mouth disease in Sichuan, China: a spatiotemporal study.Scientific reports · 2023Article
- City-level meteorological conditions modify the relationships between exposure to multiple air pollutants and the risk of pediatric hand, foot, and mouth disease in the Sichuan Basin, China.Frontiers in public health · 2023Article
- Air pollution and timing of childbirth: a retrospective survey analysis based on birth registration data of Chinese newborns.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA few studies have explored the association between meteorological factors and hand, foot, and mouth disease (HFMD) with inconsistent results. Besides, studies about the effects of air pollutants on HFMD are very limited.
methodsDaily HFMD cases among children aged 0-14 years in Shenzhen were collected from 2009 to 2017. A distributed lag nonlinear model (DLNM) model was fitted to simultaneously assess the nonlinear and lagged effects of meteorological factors and air pollutants on HFMD incidence, and to further examine the differences of the effect across different subgroups stratified by gender, age and childcare patterns.
resultsThe cumulative relative risk (cRR) (median as reference) of HFMD rose with the increase of daily temperature and leveled off at about 30 °C (cRR: 1.40, 95%CI: 1.29, 1.51). There was a facilitating effect on HFMD when relative humidity was 46.0% to 88.8% (cRR at 95th percentile: 1.18, 95%CI: 1.11, 1.27). Short daily sunshine duration (5th vs. 50th) promoted HFMD (cRR: 1.07, 95%CI: 1.02, 1.11). The positive correlation between rainfall and HFMD reversed when it exceeded 78.3 mm (cRR: 1.41, 95% CI: 1.22, 1.63). Ozone suppressed HFMD when it exceeded 104 µg /m3 (cRR at 99th percentile: 0.85, 95%CI: 0.76, 0.94). NO
conclusionsTemperature, relative humidity, sunshine duration, rainfall, ozone and NO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.