Observational studyGenes2019
Telomere Length Changes during Critical Illness: A Prospective, Observational Study.
Observational study in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Infection and telomere length: A systematic review.PloS one · 2025Pooled it
- Exploring the association between epigenetic age and intensive care unit delirium: a pilot feasibility study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Deep Biological Clocks in Critical Care Medicine: A Scoping Review Toward Translational Precision Care.Journal of personalized medicine · 2026Review
- Leukocyte telomere length change in children with obesity in the context of an isocaloric fructose restriction intervention.Diabetology & metabolic syndrome · 2025Article
- Biological age in critical care: current evidence, future prospects, and clinical implications.Frontiers in medicine · 2025Review
- Telomere-related prognostic signature for survival assessments in lung adenocarcinoma.Translational cancer research · 2024Article
- Longer ICU stay and invasive mechanical ventilation accelerate telomere shortening in COVID-19 patients 1 year after recovery.Critical care (London, England) · 2024Article
- Causal relationship between telomere length and sepsis: a bidirectional Mendelian randomization study.Scientific reports · 2024Article
- Observational
- Mediation Effect of Platelet Traits on Associations of Central Obesity with Aging Biomarkers in Rural Adults of Henan, China.Nutrients · 2022Article
- Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities.Immunity & ageing : I & A · 2022Article
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Triggering a Lethal Fight to Keep Control of the Ten-Eleven Translocase (TET)-Associated DNA Demethylation?Pathogens (Basel, Switzerland) · 2020Review
- Size matters! Peripheral blood leukocyte telomere length and survival after critical illness.The European respiratory journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveevaluation of telomere length change in acutely ill adult patients.
designBlood samples were drawn on the first and seventh day of intensive care unit (ICU) stay to assess telomere length using a polymerase chain reaction (PCR)-based technique. Demographic data collected included age, weight, admission diagnosis, baseline laboratory values (pH, C- reactive protein (CRP), serum albumin level, white blood cell count (WBC) count, platelet count), and baseline SOFA and APACHE II scores. Additional data collected during the ICU stay included a repeated WBC count, the presence of positive blood cultures and outcome data, including death in the ICU or following discharge, whether ventilated or not at ICU discharge, and destination following discharge, i.e., medical ward or rehabilitation.
settingGeneral ICU in tertiary hospital. PATIENTS: Forty patients admitted to the ICU within 72 h of hospital admission suffering from an acute illness were included in this prospective, observational study. MAIN
resultsOf the 40 patients studied, telomere shortening was noted in 21, telomere lengthening in 11, and no significant change in the other eight. The age of patients demonstrating telomere shortening was statistically significantly younger (45.4 vs. 61.5 years,
conclusionChanges in telomere length, both shortening and lengthening, were evident in the acute setting, but no associations between such changes with outcome were noted. Further studies in more homogeneous groups of patients appear to be warranted.
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Registered trials
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