Evidence map›Paper›PMID 31569790›Full record

ArticleBiomolecules2019

Exploring the Interactions of Ruthenium (II) Carbosilane Metallodendrimers and Precursors with Model Cell Membranes through a Dual Spin-Label Spin-Probe Technique Using EPR.

Riccardo Carloni, Natalia Sanz Del Olmo, Paula Ortega, Alberto Fattori, Rafael Gómez, Maria Francesca Ottaviani, Sandra García-Gallego, Michela Cangiotti, F Javier de la Mata

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Riccardo CarloniDepartment of Pure and Applied Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy. riccardocarloni93@gmail.com.ORCID 0000-0001-8052-213X
Natalia Sanz Del OlmoDepartment of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28805 Madrid, Spain.
Paula OrtegaDepartment of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28805 Madrid, Spain. paula.ortega@uah.es.
Alberto FattoriDepartment of Pure and Applied Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy. alberto.fattori@uniurb.it.ORCID 0000-0001-6468-9140
Rafael GómezDepartment of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28805 Madrid, Spain. rafael.gomez@uah.es.
Maria Francesca OttavianiDepartment of Pure and Applied Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy. maria.ottaviani@uniurb.it.ORCID 0000-0002-4681-4718
Sandra García-GallegoDepartment of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28805 Madrid, Spain. sandra.garciagallego@uah.es.
Michela CangiottiDepartment of Pure and Applied Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy. michela.cangiotti@uniurb.it.ORCID 0000-0002-5713-7740
F Javier de la MataDepartment of Organic and Inorganic Chemistry, and Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28805 Madrid, Spain. javier.delamata@uah.es.
Universidad de Alcalá · ESUniversity of Urbino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendrimers exhibit unique interactions with cell membranes, arising from their nanometric size and high surface area. To a great extent, these interactions define their biological activity and can be reported in situ by spin-labelling techniques. Schiff-base carbosilane ruthenium (II) metallodendrimers are promising antitumor agents with a mechanism of action yet to explore. In order to study their in situ interactions with model cell membranes occurring at a molecular level, namely cetyltrimethylammonium bromide micelles (CTAB) and lecithin liposomes (LEC), electron paramagnetic resonance (EPR) was selected. Both a spin probe, 4-(

Indexed as

Spin LabelsCell MembraneCetrimoniumDendrimersElectron Spin Resonance SpectroscopyHydrophobic and Hydrophilic InteractionsLecithinsLiposomesMicellesModels, MolecularOrganometallic CompoundsRutheniumSilanesSurface PropertiescarbosilaneCetrimoniumDendrimersLecithinsLiposomesMicellesOrganometallic CompoundsRutheniumSilanesSpin Labelscancercell membranedendrimerelectron paramagnetic resonancemetallodendrimerrutheniumspin probe

Identifiers

PMID31569790
PMCPMC6843795
OpenAlexW2976117414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.