Evidence map›Paper›PMID 31569690›Full record

ArticleCells2019

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells.

Bhavana Chhunchha, Eri Kubo, Dhirendra P Singh

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Bhavana ChhunchhaDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. bchhunchha@unmc.edu.ORCID 0000-0001-9613-8765
Eri KuboDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 9200293, Japan. kuboe@kanazawa-med.ac.jp.ORCID 0000-0001-6789-9311
Dhirendra P SinghDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. dpsingh@unmc.edu.
University of Nebraska Medical Center · USKanazawa Medical University · JP

Funding

Regulation and Function of Prdx6 in eye lens during Aging & Oxidative StressR01EY024589 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SINGH, DHIRENDRA P · 2014 to 2018
$1.9M
NEI NIH HHS R01 EY024589
6 · The paper itself

Abstract

Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like

Indexed as

Anticarcinogenic AgentsAntioxidantsApoptosisCells, CulturedEpithelial CellsGene Expression RegulationHumansIsothiocyanatesKruppel-Like Transcription FactorsLens, CrystallineOxidation-ReductionOxidative StressPeroxiredoxin VIPromoter Regions, GeneticReactive Oxygen SpeciesSulfoxidesAnticarcinogenic AgentsAntioxidantsIsothiocyanatesKLF9 protein, humanKruppel-Like Transcription FactorsPeroxiredoxin VIPRDX6 protein, humanReactive Oxygen SpeciessulforaphaneSulfoxidesantioxidantsKlf9Nrf2oxidative stressPrdx6sulforaphane

Identifiers

PMID31569690
PMCPMC6829349
OpenAlexW2975629170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.