Evidence map›Paper›PMID 31569678›Full record

ReviewCancers2019

Experimental Models to Define the Genetic Predisposition to Liver Cancer.

Rosa M Pascale, Maria M Simile, Graziella Peitta, Maria A Seddaiu, Francesco Feo, Diego F Calvisi

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. F1000Research · 2023
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Best Practices and Progress in Precision-Cut Liver Slice Cultures.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rosa M PascaleDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. patsper@uniss.it.ORCID 0000-0001-7612-3646
Maria M SimileDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. simile@uniss.it.
Graziella PeittaDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. graziella.85@live.it.
Maria A SeddaiuDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. maseddaiu@uniss.it.
Francesco FeoDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. feo@uniss.it.
Diego F CalvisiDepartment of Medical, Surgical and Experimental Sciences, Via P. Manzella 4, 07100 Sassari, Italy. calvisid@uniss.it.
University of Sassari · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG 19175
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a frequent human cancer and the most frequent liver tumor. The study of genetic mechanisms of the inherited predisposition to HCC, implicating gene-gene and gene-environment interaction, led to the discovery of multiple gene loci regulating the growth and multiplicity of liver preneoplastic and neoplastic lesions, thus uncovering the action of multiple genes and epistatic interactions in the regulation of the individual susceptibility to HCC. The comparative evaluation of the molecular pathways involved in HCC development in mouse and rat strains differently predisposed to HCC indicates that the genes responsible for HCC susceptibility control the amplification and/or overexpression of c-

Indexed as

genetic predispositionhepatocarcinogenesisinterspecies comparisonmodifier genesprognostic markersquantitative trait locisignal transduction

Identifiers

PMID31569678
PMCPMC6826893
OpenAlexW2977199105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.