Evidence map›Paper›PMID 31569653›Full record

ArticleCells2019

Differential Regulation of

Sangho Lee, Hoon Jang, Sohyeon Moon, Ok-Hee Lee, Sujin Lee, Jihyun Lee, Chanhyeok Park, Dong Won Seol, Hyuk Song, Kwonho Hong and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. miR-132-y TargetsBiomolecules · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Sangho LeeDepartment of Biomedical Science, CHA University, Seongnam 13488, Korea. sangho@chamc.co.kr.
Hoon JangFunctional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea. sojiro38@naver.com.
Sohyeon MoonDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. 1004sh.moon@gmail.com.
Ok-Hee LeeDepartment of Biomedical Science, CHA University, Seongnam 13488, Korea.
Sujin LeeDepartment of Biomedical Science, CHA University, Seongnam 13488, Korea. sj091895@naver.com.
Jihyun LeeDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. lsw46340@naver.com.
Chanhyeok ParkDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. chanhyeok.park3751@gmail.com.
Dong Won SeolDepartment of Biomedical Science, CHA University, Seongnam 13488, Korea. dongwonseol@gmail.com.
Hyuk SongDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. songh@konkuk.ac.kr.
Kwonho HongDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. hongk@konkuk.ac.kr.
Jin-Hoi KimDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. jhkim541@konkuk.ac.kr.ORCID 0000-0003-1232-5307
Sang Jun UhmDepartment of Animal Science and Biotechnology, Sangji Youngseo College, Wonju 26339, Korea. sjuhm@hanmail.net.
Dong Ryul LeeDepartment of Biomedical Science, CHA University, Seongnam 13488, Korea. drleedr@cha.ac.kr.
Jeong-Woong LeeFunctional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea. jwlee@kribb.re.kr.ORCID 0000-0002-2649-9677
Youngsok ChoiDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea. choiys3969@konkuk.ac.kr.ORCID 0000-0002-3862-4105
Konkuk University · KRCHA University · KRKoguryeo College · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermatogenesis is a process by which haploid cells differentiate from germ cells in the seminiferous tubules of the testes. TLE3, a transcriptional co-regulator that interacts with DNA-binding factors, plays a role in the development of somatic cells. However, no studies have shown its role during germ cell development in the testes. Here, we examined TLE3 expression in the testes during spermatogenesis. TLE3 was highly expressed in mouse testes and was dynamically regulated in different cell types of the seminiferous tubules, spermatogonia, spermatids, and Sertoli cells, but not in the spermatocytes. Interestingly, TLE3 was not detected in Sertoli cells on postnatal day 7 (P7) but was expressed from P10 onward. The microarray analysis showed that the expression of numerous genes changed upon

Indexed as

Cell DifferentiationSpermatogenesisAnimalsCells, CulturedCo-Repressor ProteinsGene Expression Regulation, DevelopmentalMaleMiceMice, Inbred C57BLRNA, Small InterferingSeminiferous TubulesSertoli CellsTestisCo-Repressor ProteinsRNA, Small InterferingTle3 protein, mouseSertoli cellspermatogenesisTestisTLE3

Identifiers

PMID31569653
PMCPMC6848928
OpenAlexW2976290449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.