Evidence map›Paper›PMID 31569432›Full record

ArticleInternational journal of molecular sciences2019

Effect of Lactoferrin on the Expression Profiles of Long Non-coding RNA during Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

Yan Xu, Jing-Jing An, Dina Tabys, Yin-Dan Xie, Tian-Yu Zhao, Hao-Wei Ren, Ning Liu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. LINC00341 promotes fracture healing through downregulation of miR-133a-3p.Journal of orthopaedic surgery and research · 2025
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  8. The Role of SIRT3 in the Osteoporosis.Frontiers in endocrinology · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yan XuKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. xuyan1991521@163.com.ORCID 0000-0001-7108-7834
Jing-Jing AnKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. anjingloveme@163.com.
Dina TabysKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. tabysdina@gmail.com.
Yin-Dan XieKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. xieyindan99@163.com.
Tian-Yu ZhaoKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. 13091456816@163.com.
Hao-Wei RenKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. renhw800903@126.com.
Ning LiuKey Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China. ningliuneau@hotmail.com.
Northeast Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactoferrin (LF) has demonstrated stimulation of osteogenic differentiation of mesenchymal stem cells (MSCs). Long non-coding RNAs (lncRNAs) participate in regulating the osteogenic differentiation processes. However, the impact of LF on lncRNA expression in MSC osteogenic differentiation is poorly understood. Our aim was to investigate the effects of LF on lncRNAs expression profiles, during osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs), by RNA sequencing. A total number of 1331 putative lncRNAs were identified in rBMSCs during osteogenic differentiation in the study. LF influenced the expression of 120 lncRNAs (differentially expressed lncRNAs [DELs], Fold change > 1.5 or < -1.5;

Indexed as

Cell DifferentiationGene Expression RegulationGene OntologyHumansLactoferrinMesenchymal Stem CellsOsteogenesisRNA, Long NoncodingLactoferrinRNA, Long Noncodingbone marrow mesenchymal stem cellslactoferrinlncRNAsosteogenic differentiationRNA-seq

Identifiers

PMID31569432
PMCPMC6801644
OpenAlexW2976312815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.