Evidence map›Paper›PMID 31569409›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents.

Felicia D'Andrea, Giulia Vagelli, Carlotta Granchi, Lorenzo Guazzelli, Tiziano Tuccinardi, Giulio Poli, Dalila Iacopini, Filippo Minutolo, Valeria Di Bussolo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Developments in Carbohydrate-Based Metzincin Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Felicia D'AndreaDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. felicia.dandrea@unipi.it.ORCID 0000-0003-1517-4911
Giulia VagelliDipartimento di Chimica e Chimica Industriale, Università di Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy. vagelligiulia@gmail.com.
Carlotta GranchiDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. carlotta.granchi@unipi.it.ORCID 0000-0002-5849-0722
Lorenzo GuazzelliDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. lorenzo.guazzelli@unipi.it.ORCID 0000-0003-4655-2946
Tiziano TuccinardiDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. tiziano.tuccinardi@unipi.it.ORCID 0000-0002-6205-4069
Giulio PoliDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. giulio.poli@unipi.it.
Dalila IacopiniDipartimento di Chimica e Chimica Industriale, Università di Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy. dalila.iacopini@phd.unipi.it.
Filippo MinutoloDipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. filippo.minutolo@unipi.it.ORCID 0000-0002-3312-104X
Valeria Di BussoloDipartimento di Chimica e Chimica Industriale, Università di Pisa, Via G. Moruzzi 3, 56124 Pisa, Italy. valeria.dibussolo@unipi.it.
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conjugation of known biologically active molecules to carbohydrate frameworks represents a valuable option for the preparation of hybrid, structurally-related families of compounds with the aim of modulating their biological response. Therefore, we present here a study on the preparation of d-

Indexed as

Antineoplastic AgentsBinding SitesCell Line, TumorCell ProliferationChemistry Techniques, SyntheticDose-Response Relationship, DrugEnzyme InhibitorsGlycoconjugatesHumansL-Lactate DehydrogenaseMolecular StructureProtein BindingStructure-Activity RelationshipAntineoplastic AgentsEnzyme InhibitorsGlycoconjugatesL-Lactate Dehydrogenaseanticancer agentsglycoconjugatesLDH inhibitors

Identifiers

PMID31569409
PMCPMC6804087
OpenAlexW2976825395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.