Evidence map›Paper›PMID 31569374›Full record

ArticleAntibiotics (Basel, Switzerland)2019

Evaluation of Immunocompetent Urinary Tract Infected Balb/C Mouse Model For the Study of Antibiotic Resistance Development Using

Ashok Chockalingam, Sharron Stewart, Lin Xu, Adarsh Gandhi, Murali K Matta, Vikram Patel, Leonard Sacks, Rodney Rouse

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. The Role ofInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. UropathogenicFrontiers in cellular and infection microbiology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems.Frontiers in cellular and infection microbiology · 2021
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ashok ChockalingamOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Sharron StewartOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Lin XuOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Adarsh GandhiOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Murali K MattaOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.ORCID 0000-0002-0333-5020
Vikram PatelOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Leonard SacksOffice of Medical Policy; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA.
Rodney RouseOffice of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, Silver Spring, MD 20993, USA. Rodney.Rouse@fda.hhs.gov.
United States Food and Drug Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary tract infections (UTI) are common worldwide and are becoming increasingly difficult to treat because of the development of antibiotic resistance. Immunocompetent murine models of human UTI have been used to study pathogenesis and treatment but not for investigating resistance development after treatment with antibiotics. In this study, intravesical inoculation of uropathogenic

Indexed as

ampicillinantibiotic resistanceCFT073 UPEC strainciprofloxacinfosfomycinMouse UTI model

Identifiers

PMID31569374
PMCPMC6963567
OpenAlexW2975021635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.