Evidence map›Paper›PMID 31569362›Full record

ArticleMaterials (Basel, Switzerland)2019

Antibacterial Properties of a Novel Zirconium Phosphate-Glycinediphosphonate Loaded with Either Zinc or Silver.

Davide Campoccia, Stefano Ravaioli, Riccardo Vivani, Anna Donnadio, Eleonora Vischini, Alessandro Russo, Livia Visai, Carla Renata Arciola, Lucio Montanaro, Morena Nocchetti

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Davide CampocciaLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy. davide.campoccia@ior.it.ORCID 0000-0002-3336-0219
Stefano RavaioliLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy. stefano.ravaioli@ior.it.
Riccardo VivaniDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy. riccardo.vivani@unipg.it.
Anna DonnadioDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy. anna.donnadio@unipg.it.
Eleonora VischiniDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy. eleonoravischini@yahoo.it.
Alessandro RussoClinica Ortopedica e Traumatologica II, IRCCS Rizzoli Orthopaedic Institute, 40136 Bologna, Italy. alessandro.russo@ior.it.
Livia VisaiMolecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy and Department of Occupational Medicine, Toxicology and Environmental Risks, Istituti Clinici Scientifici (ICS) Maugeri, IRCCS, 27100 Pavia, Italy. livia.visai@unipv.it.ORCID 0000-0003-1181-3632
Carla Renata ArciolaLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy. carlarenata.arciola@ior.it.ORCID 0000-0003-0382-0066
Lucio MontanaroLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, via di Barbiano 1/10, 40136 Bologna, Italy. lucio.montanaro@unibo.it.
Morena NocchettiDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1, 06123 Perugia, Italy. morena.nocchetti@unipg.it.ORCID 0000-0003-2927-1130

Funding

contribution by "5 per mille" grants for Health Research to the IRCCS Rizzoli Orthopaedic Institute of Bologna 2018-2019
6 · The paper itself

Abstract

A novel compound consisting of a zirconium phosphate-glycinediphosphonate (ZPGly) has recently been introduced. This 2D-structured material forming nanosheets was exfoliated under appropriate conditions, producing colloidal aqueous dispersions (ZPGly-e) which were then loaded with zinc (Zn/ZPGly) or silver ions. Silver ions were subsequently reduced to produce metallic silver nanoparticles on exfoliated ZPGly nanosheets (Ag@ZPGly). In the search for new anti-infective materials, the present study investigated the properties of colloidal dispersions of ZPGly-e, Zn/ZPGly, and Ag@ZPGly. Ag@ZPGly was found to be a bactericidal material and was assayed to define its minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) on the five most prevalent pathogens of orthopaedic implant infections, namely:

Indexed as

antibacterial activityE. coliE. faecalisimplant infectionsP. aeruginosaS. aureusS. epidermidissilver nanoparticleszirconium phosphonates

Identifiers

PMID31569362
PMCPMC6804034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.