Evidence map›Paper›PMID 31569149›Full record

ArticleEpidemiology (Cambridge, Mass.)2019

The Relation of Birth Weight and Adiposity Across the Life Course to Semen Quality in Middle Age.

Linda G Kahn, Elizabeth M Widen, Teresa Janevic, Nadine Straka, Xinhua Liu, Piera M Cirillo, Barbara A Cohn, Germaine M Buck Louis, Pam Factor-Litvak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Linda G KahnFrom the Department of Pediatrics, New York University School of Medicine, New York, NY.
Elizabeth M WidenDepartment of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX.
Teresa JanevicDepartment of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY.
Nadine StrakaDepartment of Pediatrics, Boston Children's Hospital, Boston, MA.
Xinhua LiuDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY.
Piera M CirilloChild Health and Development Studies, Center for Research on Women's and Children's Health, Public Health Institute, Berkeley, CA.
Barbara A CohnChild Health and Development Studies, Center for Research on Women's and Children's Health, Public Health Institute, Berkeley, CA.
Germaine M Buck LouisDivision of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, MD.
Pam Factor-LitvakDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
Columbia University · USPublic Health Institute · USBoston Children's Hospital · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USIcahn School of Medicine at Mount Sinai · USNew York University · USThe University of Texas at Austin · US

Funding

Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Elizabeth T. Gershoff · 2017 to 2026
$5.2M
Prenatal Organochlorine Exposure and Male ReproductionR01ES012231 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FACTOR-LITVAK, PAM R · 2004 to 2010
$2.1M
Pregnancy weight trajectories and offspring adiposityR00HD086304 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI WIDEN, ELIZABETH MARIE · 2018 to 2020
$744k
Interdisciplinary Training in Nutritional and Population Health SciencesT32DK091227 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SUSSER, EZRA S., WOLGEMUTH, DEBRA J. · 2011 to 2015
$606k
Prenatal exposure to a mixture of EDCs, maternal thyroid function and child neuroK99ES020364 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HORTON, MEGAN K · 2011 to 2012
$246k
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthK99ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2019 to 2020
$220k
NICHD NIH HHS P2C HD042849NICHD NIH HHS R00 HD086304NIEHS NIH HHS K99 ES020364NIEHS NIH HHS K99 ES030403NIEHS NIH HHS R01 ES012231
6 · The paper itself

Abstract

backgroundStudies of body mass index and semen quality have reported mixed results, but almost all were cross-sectional and many were conducted in selected populations. Longitudinal studies in population-based cohorts are necessary to identify how timing and duration of excess adiposity may affect semen quality.

methodsIn 193 members of the Child Health and Development Studies birth cohort, we examined associations of birth weight and adiposity at six time points spanning early childhood and adulthood with sperm concentration, motility, and morphology at mean age 44 years, as well as with corresponding 2010 World Health Organization (WHO) subfertility reference levels.

resultsBirth weight for gestational age percentile was positively associated with square-root sperm concentration (regression coefficient B [95% confidence interval] = 0.02 × 103 sperm/ml [0.004, 0.04]). Overweight/obesity in men's 20s was associated with lower percent progressive motility (B =-5.2 [-9.9, -0.63]), higher odds of low motility (odds ratio (OR) = 2.4 [1.3, 4.4]), and higher odds of poor morphology (OR = 1.9 [0.94, 3.8]). Those who were overweight/obese in their 20s were also more likely to meet two or three WHO subfertility criteria (OR = 3.9 [1.6, 9.4]) compared with normal-weight men. Each additional adult decade in which a participant was overweight/obese was associated with higher odds of low motility (OR = 1.3 [0.96, 1.6]) and higher odds of meeting two or three WHO subfertility criteria (OR = 1.5 [1.0, 2.2]).

conclusionsIn our data, associations among adiposity and sperm concentration, motility, and morphology varied according to timing and duration of exposure, potentially reflecting different biological mechanisms that influence these semen parameters.

Indexed as

AdiposityBirth WeightSemen AnalysisAdultHumansInfertility, MaleLongitudinal StudiesMaleMiddle AgedRisk FactorsSperm CountSperm Motility

Identifiers

PMID31569149
PMCPMC7055633
OpenAlexW2979178276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.