Evidence map›Paper›PMID 31568832›Full record

ArticleMolecular plant2020

Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.

Heejin Yoo, George H Greene, Meng Yuan, Guoyong Xu, Derek Burton, Lijing Liu, Jorge Marqués, Xinnian Dong

Open access · bronzeAbstract read
In one paragraph

Article in Molecular plant, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Proline Dehydrogenase GeneJournal of fungi (Basel, Switzerland) · 2026
    Article
  4. CabioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. The redox rhythm gates immune-induced cell death distinctly from the genetic clock.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Protein Dynamics in Plant Immunity: Insights into Plant-Pest Interactions.International journal of molecular sciences · 2024
    Review
  15. Article
  16. HScience (New York, N.Y.) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Heejin YooHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
George H GreeneHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
Meng YuanNational Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research (Wuhan), Huazhong Agricultural University, 430070 Wuhan, China.
Guoyong XuHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
Derek BurtonHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
Lijing LiuHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
Jorge MarquésHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA.
Xinnian DongHoward Hughes Medical Institute, Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA. Electronic address: xdong@duke.edu.
Duke University · USHoward Hughes Medical Institute · USHuazhong Agricultural University · CN

Funding

Genetics Training Grant-Year 26T32GM007754 · NIGMS · DUKE UNIVERSITY · PI HAASE, STEVEN B · 1985 to 2019
$8.3M
Salicylic Acid in Immunity and Health: A Small Phytohormone with Big Physiological ImpactsR35GM118036 · NIGMS · DUKE UNIVERSITY · PI Xinnian Dong · 2016 to 2026
$4.0M
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM118036NIGMS NIH HHS T32 GM007754
6 · The paper itself

Abstract

Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity, when plants recognize microbe-associated molecular patterns. However, it is not fully known whether translational regulation also occurs in subsequent immune responses, such as effector-triggered immunity (ETI). In this study, we performed genome-wide ribosome profiling in Arabidopsis upon RPS2-mediated ETI activation and discovered that specific groups of genes were translationally regulated, mostly in coordination with transcription. These genes encode enzymes involved in aromatic amino acid, phenylpropanoid, camalexin, and sphingolipid metabolism. The functional significance of these components in ETI was confirmed by genetic and biochemical analyses. Our findings provide new insights into diverse translational regulation of plant immune responses and demonstrate that translational coordination of metabolic gene expression is an important strategy for ETI.

Indexed as

ArabidopsisArabidopsis ProteinsGene Expression Regulation, PlantGenes, PlantPlant DiseasesPlant ImmunityProtein Processing, Post-TranslationalPseudomonas syringaeSignal TransductionTranscription FactorsArabidopsis ProteinsRPS2 protein, ArabidopsisTranscription Factorseffector-triggered immunity, ETIhelper receptorsphenylalaninephenylpropanoidsribosome profilingtranslational regulation

Identifiers

PMID31568832
PMCPMC6946852
OpenAlexW2976528446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.