Evidence map›Paper›PMID 31568724›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2019

Contact Killing of Gram-Positive and Gram-Negative Bacteria on PDMS Provided with Immobilized Hyperbranched Antibacterial Coatings.

Jia Jia Dong, Agnieszka Muszanska, Fei Xiang, Richard Falkenberg, Betsy van de Belt-Gritter, Ton Loontjens

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  12. Antimicrobial TiOChemical engineering journal (Lausanne, Switzerland : 1996) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia Jia DongDepartment of Polymer Chemistry , Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4 , 9747 AG Groningen , The Netherlands.
Agnieszka MuszanskaDepartment of Biomedical Engineering , University of Groningen and University Medical Center Groningen , Antonius Deusinglaan 1 , 9713 AV Groningen , The Netherlands.
Fei XiangDepartment of Polymer Chemistry , Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4 , 9747 AG Groningen , The Netherlands.
Richard FalkenbergAtos Medical Research , Kraftgatan 8 , 242 35 Hörby , Sweden.
Betsy van de Belt-GritterDepartment of Biomedical Engineering , University of Groningen and University Medical Center Groningen , Antonius Deusinglaan 1 , 9713 AV Groningen , The Netherlands.
Ton LoontjensDepartment of Polymer Chemistry , Zernike Institute for Advanced Materials, University of Groningen , Nijenborgh 4 , 9747 AG Groningen , The Netherlands.ORCID 0000-0002-6993-6515

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we describe in detail the preparation and application of antibacterial coatings on PDMS (poly(dimethylsiloxane)) and the contact-killing properties with 10 bacterial strains. Our aim was to develop a generally applicable coating to prevent biomaterial acquired infections, which is the major mode of failure of biomedical implants. In the first step, the surface was provided with a hydrophobic hyperbranched coating resin that was covalently attached to PDMS, mediated by an appropriate coupling agent. The coupling agent contained a siloxane group that reacts covalently with the silanol groups of air-plasma-treated PDMS and a blocked isocyanate enabling covalent coupling with the amino groups of the hyperbranched coating resins. The coating resins were functionalized with a polyethylenimine and subsequently quaternized with bromohexane and iodomethane. The coatings were highly effective against Gram-positive bacteria (five strains) and sufficiently active against Gram-negative bacteria (five stains). The killing effect on the latter group was strongly enhanced by adding a permeabilizer (EDTA). The biocidal efficacy was not influenced by the presence of (saliva) proteins.

Indexed as

Anti-Bacterial AgentsCoated Materials, BiocompatibleDimethylpolysiloxanesGram-Negative BacteriaGram-Positive BacteriaAnti-Bacterial AgentsbaysilonCoated Materials, BiocompatibleDimethylpolysiloxanes

Identifiers

PMID31568724
PMCPMC6822135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.