ArticleBrain and behavior2019
Aberrant patterns of default-mode network functional connectivity associated with metabolic syndrome: A resting-state study.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.Frontiers in aging neuroscience · 2026Article
- Disruption of prefrontal and superior temporal gyrus white matter networks in antipsychotic-treated schizophrenia with comorbid metabolic syndrome.Frontiers in psychiatry · 2026Article
- Time-Varying Spatial Propagation of Brain Networks in fMRI Data.Human brain mapping · 2025Article
- Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.Brain imaging and behavior · 2024Article
- Article
- A functional connectome signature of blood pressure in >30 000 participants from the UK biobank.Cardiovascular research · 2023Article
- Effects of hypertension and aging on brain function in spontaneously hypertensive rats: a longitudinal resting-state functional magnetic resonance imaging study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Intrinsic Therapeutic Link between Recuperative Cerebellar Con-Nectivity and Psychiatry Symptom in Schizophrenia Patients with Comorbidity of Metabolic Syndrome.Life (Basel, Switzerland) · 2023Article
- Altered Calcium Permeability of AMPA Receptor Drives NMDA Receptor Inhibition in the Hippocampus of Murine Obesity Models.Molecular neurobiology · 2022Article
- Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults.Frontiers in integrative neuroscience · 2022Article
- Article
- Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Association between metabolic syndrome and resting-state functional brain connectivity.Neurobiology of aging · 2021Article
- Metabolic syndrome components moderate the association between executive function and functional connectivity in the default mode network.Brain imaging and behavior · 2021Article
- Aberrant patterns of default-mode network functional connectivity associated with metabolic syndrome: A resting-state study.Brain and behavior · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMetabolic syndrome (MetS) is a clustering of three or more cardiovascular risk factors (RF), including hypertension, obesity, high cholesterol, or hyperglycemia. MetS and its component RFs are more prevalent in older age, and can be accompanied by alterations in brain structure. Studies have shown altered functional connectivity (FC) in samples with individual RFs as well as in clinical populations that are at higher risk to develop MetS. These studies have indicated that the default mode network (DMN) may be particularly vulnerable, yet little is known about the overall impact of MetS on FC in this network.
methodsIn this study, we evaluated the integrity of FC to the DMN in participants with MetS relative to non-MetS individuals. Using a seed-based connectivity analysis approach, resting-state functional MRI (fMRI) data were analyzed, and the FC measures among the DMN seed (isthmus of the cingulate) and rest of the brain voxels were estimated.
resultsParticipants with MetS demonstrated reduced positive connectivity between the DMN seed and left superior frontal regions, and reduced negative connectivity between the DMN seed and left superior parietal, left postcentral, right precentral, right superior temporal and right superior parietal regions, after accounting for age- and sex-effects.
conclusionsOur results suggest that MetS is associated with alterations in FC between the DMN and other regions of the brain. Furthermore, these results indicate that the overall burden of vascular RFs associated with MetS may, in part, contribute to the pathophysiology underlying aberrant FC in the DMN.
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