ArticleBrain and behavior2019
Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.Human brain mapping · 2026Article
- Empathic Accuracy in Adolescent Girls with Turner Syndrome.Journal of autism and developmental disorders · 2022Article
- Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure.Psychiatry research. Neuroimaging · 2021Article
- Article
- Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.Brain and behavior · 2019Article
- Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionEmotional and behavioral control is necessary self-regulatory processes to maintain stable goal-driven behavior. Studies indicate that variance in these executive function (EF) processes is related to morphological features of the brain and white matter (WM) differences. Furthermore, sex hormone level may modulate circuits in the brain important for cognitive function.
methodsWe aimed to investigate the structural neural correlates of EF behavior in gray matter (GM) and WM while taking into account estradiol level, in an adolescent population. The present study obtained neuroimaging behavioral and physiological data from the National Institute of Health's Pediatric Database (NIHPD). We analyzed the relationship between cortical morphometry and structural connectivity (N = 55), using a parent-administered behavioral monitoring instrument (Behavior Rating Inventory of Executive Function-BRIEF), estradiol level, as well as their interaction.
resultsExecutive function behavior and estradiol level related to bidirectional associations with cortical morphometry in the right posterior dorsolateral prefrontal cortex (pDLPFC) and primary motor cortex (PMC), as well as fractional anisotropy (FA) in the forceps major and minor. Lastly, the interaction of EF behavior and estradiol level related to decreased volume in the right PMC and was linked to altered FA in the right inferior fronto-occipital fasciculus (iFOF).
conclusionsThe study provides evidence that the relationship between EF behavior and estradiol level related to bidirectional GM and WM differences, implying estradiol level has an influence on the putative structural regions underlying EF behavior. The findings represent a crucial link between EF behavior and hormonal influence on brain structure in adolescence.
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