Evidence map›Paper›PMID 31568661›Full record

Observational studyCNS neuroscience & therapeutics2020

Implementation of multimodal computed tomography in a telestroke network: Five-year experience.

Carlos Garcia-Esperon, Frode Soderhjelm Dinkelspiel, Ferdi Miteff, Shyam Gangadharan, Tom Wellings, Bill O Brien, James Evans, Tom Lillicrap, Jelle Demeestere, Andrew Bivard and 4 more

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The global impact of COVID-19 on acute stroke care.CNS neuroscience & therapeutics · 2020
    Article
  9. Observational
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Carlos Garcia-EsperonDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.ORCID 0000-0001-8843-5890
Frode Soderhjelm DinkelspielKarolinska Institutet, Stockholm, Sweden.
Ferdi MiteffDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.
Shyam GangadharanDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.
Tom WellingsDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.
Bill O BrienNeurosciences Department, Gosford Hospital, Central Coast Local Health District, Gosford, NSW, Australia.
James EvansNeurosciences Department, Gosford Hospital, Central Coast Local Health District, Gosford, NSW, Australia.
Tom LillicrapDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.
Jelle DemeestereNeurology Department, Leuven University Hospital, Leuven, Belgium.
Andrew BivardDepartment of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Mark ParsonsHunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia.
Chris Levi
Neil James SprattDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia.
Northern NSW Telestroke investigators
John Hunter Hospital · AUGosford Hospital · AUThe Royal Melbourne Hospital · AUKarolinska Institutet · SEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPenumbral selection is best-evidence practice for thrombectomy in the 6-24 hour window. Moreover, it helps to identify the best responders to thrombolysis. Multimodal computed tomography (mCT) at the primary centre-including noncontrast CT, CT perfusion, and CT angiography-may enhance reperfusion therapy decision-making. We developed a network with five spoke primary stroke sites and assessed safety, feasibility, and influence of mCT in rural hospitals on decision-making for thrombolysis.

methodsConsecutive patients assessed via telemedicine from April 2013 to June 2018. Clinical outcomes were measured, and decision-making compared using theoretical models for reperfusion therapy applied without mCT guidance. Symptomatic intracranial hemorrhage (sICH) was assessed according to Safe Implementation of Treatments in Stroke Thrombolysis Registry criteria.

resultsA total of 334 patients were assessed, 240 received mCT, 58 were thrombolysed (24.2%). The mean age of thrombolysed patients was 70 years, median baseline National Institutes of Health Stroke Scale was 10 (IQR 7-18) and 23 (39.7%) had a large vessel occlusion. 1.7% had sICH and 3.5% parenchymal hematoma. Three months poststroke, 55% were independent, compared with 70% in the non-thrombolysed group.

conclusionImplementation of CTP in rural centers was feasible and led to high thrombolysis rates with low rates of sICH.

Indexed as

AgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedMultimodal ImagingNew South WalesProspective StudiesRetrospective StudiesStrokeTelemedicineThrombolytic TherapyTime FactorsTomography, X-Ray Computedacute stroke therapycoreCT perfusionmultimodal CTpenumbratelestroke

Identifiers

PMID31568661
PMCPMC7052799
OpenAlexW2979188541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.