ArticleJournal of veterinary internal medicine2019
Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of a Single Oral Dose of Imepitoin on Veterinary Visit-Related Stress in Cats: An Open-Label Pilot Study.Veterinary sciences · 2026Article
- Firework aversion in cats and dogs as reported by Dutch animal owners.Veterinary and animal science · 2024Article
- Is It Possible to Mitigate Fear of Fireworks in Dogs? A Study on the Behavioural and Physiological Effects of a Psychoactive Supplement.Animals : an open access journal from MDPI · 2024Article
- Pilot Study on the Efficacy and Safety of Long-Term Oral Imepitoin Treatment for Control of (Thunder)Storm-Associated Noise Phobia/Noise Aversion in Dogs Using an Individualized-Dose Titration Approach.Animals : an open access journal from MDPI · 2024Article
- A Multidimensional Evaluation of the Factors in the Animal Welfare Assessment Grid (AWAG) That Are Associated with, and Predictive of, Behaviour Disorders in Dogs.Animals : an open access journal from MDPI · 2024Article
- Therapy and Prevention of Noise Fears in Dogs-A Review of the Current Evidence for Practitioners.Animals : an open access journal from MDPI · 2023Review
- Influence of Perch-Provision Timing on Anxiety and Fearfulness in Laying Hens.Animals : an open access journal from MDPI · 2023Article
- Clinical Animal Behaviour: Paradigms, Problems and Practice.Animals : an open access journal from MDPI · 2022Review
- Effects of Housing System on Anxiety, Chronic Stress, Fear, and Immune Function in Bovan Brown Laying Hens.Animals : an open access journal from MDPI · 2022Article
- The Impact of Noise Anxiety on Behavior and Welfare of Horses from UK and US Owner's Perspective.Animals : an open access journal from MDPI · 2022Article
- Evaluation of repeated dosing of a dexmedetomidine oromucosal gel for treatment of noise aversion in dogs over a series of noise events.The Veterinary record · 2020Article
- Imepitoin for treatment of idiopathic head tremor syndrome in dogs: A randomized, blinded, placebo-controlled study.Journal of veterinary internal medicine · 2020Article
- Impact of canine epilepsy on judgement and attention biases.Scientific reports · 2020Article
- Development and Psychometric Validation of the Lincoln Canine Anxiety Scale.Frontiers in veterinary science · 2020Article
- Owner Personality, Owner-Dog Attachment, and Canine Demographics Influence Treatment Outcomes in Canine Behavioral Medicine Cases.Frontiers in veterinary science · 2020Article
- Use of Detomidine Oromucosal Gel for Alleviation of Acute Anxiety and Fear in Horses: A Pilot Study.Frontiers in veterinary science · 2020Article
- Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs.Journal of veterinary internal medicine · 2019Article
- Does imepitoin reduce signs of fear and anxiety in dogs frightened by loud noises?Veterinary evidenceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundNoise phobia is a common behavior problem in dogs for which there are limited treatment options.
objectiveTo evaluate the efficacy and safety of imepitoin in comparison to placebo for the control of anxiety and fear associated with noise phobia in dogs. ANIMALS: Two hundred thirty-eight client-owned dogs with noise phobia were recruited in veterinary clinics.
methodsThis placebo-controlled, randomized, double-blinded, clinical trial used a predictable noise event as eliciting context, the traditional New Year's Eve fireworks in Germany and the Netherlands. Owners began treatment 2 days before the anticipated noise event with administration of either imepitoin 30 mg/kg body weight Q12h or placebo for 3 consecutive days. On New Year's Eve, owners noted their observations of their dog's fear and anxiety behavior at 1600, 2200, 0020, and 0100 hours and scored the overall treatment effect on the following day.
resultsIn the 16-item owner report of fear and anxiety signs, fear and anxiety behaviors were significantly reduced under imepitoin treatment compared to placebo (delta -6.1 scoring points; P < .0001). A significantly higher proportion of owners reported a good or excellent overall treatment effect in the imepitoin group compared to placebo (odds ratio 4.689; 95% CI, 2.79-7.89; P < .0001).
conclusionImepitoin effectively controls fear and anxiety associated with noise phobia in dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.