Evidence map›Paper›PMID 31568615›Full record

ArticleJournal of veterinary internal medicine2019

Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.

Hannah J Sargent, Rosanne E Jepson, Yu-Mei Chang, Vincent C Biourge, Esther S Bijsmans, Jonathan Elliott

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Hannah J SargentDepartment of Comparative Biomedical Science, Royal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0003-4702-2541
Rosanne E JepsonDepartment of Clinical Science and Services Royal Veterinary College, University of London, London, United Kingdom.
Yu-Mei ChangResearch Support Office, Royal Veterinary College, University of London, London, United Kingdom.ORCID https://orcid.org/0000-0001-6388-9626
Vincent C BiourgeResearch and Development, Royal Canin, Aimargues, France.
Esther S BijsmansResearch and Development, Royal Canin, Aimargues, France.
Jonathan ElliottDepartment of Comparative Biomedical Science, Royal Veterinary College, University of London, London, United Kingdom.
University of London · GBBouygues (France) · FR

Funding

Royal Canin
6 · The paper itself

Abstract

backgroundFibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is increased in azotemic cats with chronic kidney disease (CKD) and predictive of the onset of azotemia in older cats. The introduction of symmetric dimethylarginine (SDMA) as a biomarker of glomerular filtration rate has led to the identification of cats in which SDMA is increased, but plasma creatinine concentrations remains within reference range. There is currently little understanding of the metabolic changes present in such cats.

objectivesTo examine the relationship between plasma FGF23 and SDMA concentrations in non-azotemic geriatric cats. ANIMALS: Records of a cross section of client-owned cats (n = 143) without azotemic CKD.

methodsClinicopathological information was obtained from cats (≥ 9 years) from records of 2 first opinion practices. The relationship between plasma SDMA and FGF23 concentrations was examined using Spearman's correlation and variables compared using the Mann-Whitney U test.

resultsCats with increased SDMA concentrations had significantly higher plasma FGF23 (P < .001) and creatinine (P < .001) concentrations compared to cats with SDMA concentrations within reference range. A weak positive relationship was demonstrated between plasma FGF23 and SDMA concentrations (r = .35, P < .001) and between plasma FGF23 and creatinine (r = .23, P = .005) concentrations. CONCLUSIONS AND CLINICAL IMPORTANCE: More cats with increased SDMA concentrations had higher FGF23 concentrations than those with SDMA concentrations within the reference range, suggesting the presence of an alteration in phosphate homeostasis. Further studies are warranted to identify influencing factors and to explore the utility of FGF23 concentration to inform management of cats with early stage CKD.

Indexed as

AgingAnimalsArginineBiomarkersCatsCross-Sectional StudiesFemaleFibroblast Growth FactorsMaleReference ValuesArginineBiomarkersFibroblast Growth Factorssymmetric dimethylarginineazotemiafelinephosphaterenal

Identifiers

PMID31568615
PMCPMC6872607
OpenAlexW2977441331

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.