Evidence map›Paper›PMID 31568563›Full record

ReviewAnimal genetics2019

Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.

T Raudsepp, C J Finno, R R Bellone, J L Petersen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animal genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  12. Rewilded horses in European nature conservation - a genetics, ethics, and welfare perspective.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  13. Article
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  15. Review
  16. Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

T RaudseppDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Research, Texas A&M University, College Station, TX, 77843, USA.ORCID https://orcid.org/0000-0003-2276-475X
C J FinnoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.ORCID https://orcid.org/0000-0001-5924-0234
R R BelloneDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.ORCID https://orcid.org/0000-0001-8838-7227
J L PetersenDepartment of Animal Science, University of Nebraska, Lincoln, NE, 68583-0908, USA.ORCID https://orcid.org/0000-0001-5438-8555

Funding

Molecular pathogenesis of alpha-tocopherol associated neuroaxonal dystrophy in anK01OD015134 · OD · UNIVERSITY OF MINNESOTA · PI FINNO, CARRIE · 2013 to 2017
$599k
CSR NIH HHS K01OD015134National Institute of Food and Agriculture 2012-67015-19632National Institute of Food and Agriculture 2019-67015-29322NCATS NIH HHS L40 TR001136NIH HHS K01 OD015134
6 · The paper itself

Abstract

The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics. At the core of this progress is the continuing improvement of the quality, contiguity and completeness of the reference genome, and its functional annotation. Recent achievements include the release of the next version of the reference genome (EquCab3.0) and generation of a reference sequence for the Y chromosome. Horse satellite-free centromeres provide unique models for mammalian centromere research. Despite extremely low genetic diversity of the Y chromosome, it has been possible to trace patrilines of breeds and pedigrees and show that Y variation was lost in the past approximately 2300 years owing to selective breeding. The high-quality reference genome has led to the development of three different SNP arrays and WGSs of almost 2000 modern individual horses. The collection of WGS of hundreds of ancient horses is unique and not available for any other domestic species. These tools and resources have led to global population studies dissecting the natural history of the species and genetic makeup and ancestry of modern breeds. Most importantly, the available tools and resources, together with the discovery of functional elements, are dissecting molecular causes of a growing number of Mendelian and complex traits. The improved understanding of molecular underpinnings of various traits continues to benefit the health and performance of the horse whereas also serving as a model for complex disease across species.

Indexed as

AnimalsCentromereDomesticationGenomeHorsesMalePedigreePhysical Conditioning, AnimalPolymorphism, Single NucleotidePopulation DynamicsY Chromosomeancient genomescentromerescomplex traitsdomesticationMendelian traitsmodern breedssignatures of selectionY chromosome

Identifiers

PMID31568563
PMCPMC6825885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.