ArticlePloS one2019
Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Frequency of coexistent eye diseases and cognitive impairment or dementia: a systematic review and meta-analysis.Eye (London, England) · 2023Pooled it
- Self-reported Visual Difficulty, Age-related Eye Disease, and Neuropsychiatric Outcomes in Older Adults.Ophthalmic epidemiology · 2025Article
- Prevalence of visual impairment in older people living with dementia and its impact: a scoping review.BMC geriatrics · 2023Article
- Integrated Analysis of DNA methylation and transcriptome profile to identify key features of age-related macular degeneration.Bioengineered · 2021Article
- Ophthalmic conditions associated with dementia risk: The Cardiovascular Health Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPrevious studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is higher in AD patients than non-AD controls by using histopathology to definitively diagnose AD.
methodsThis was a retrospective case-control study utilizing diagnostic information extracted from autopsy reports of patients age 75 and above, including 115 with a neuropathological diagnosis of AD and 57 age-matched normal controls.
resultsThe rate of AMD was not significantly higher in AD cases (53.0%) than in controls (59.6%) (z = 0.820, p = 0.794). AMD severity as determined by Sarks score was similar between AD patients and controls (χ2 = 2.96, p = 0.706). There was also no significant association between Braak stage of AD severity and AMD (χ2 = 4.55, p = 0.602). DISCUSSION: No significant effect of AD diagnosis or pathologic severity on AMD comorbidity was found, suggesting that any shared mechanisms between AMD and AD may be nondeterministic.
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