Observational studyMedicine2019
Clinical significance of serum magnesium levels in patients with heart failure with preserved ejection fraction.
Observational study in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Serum NT-proBNP Concentrations in Pediatric Patients with a History of Idiopathic Cardiac Arrhythmias: A Pilot Study.International journal of molecular sciences · 2026Article
- Dapagliflozin Prevents Heart Failure With Preserved Ejection Fraction by Inhibiting the Sodium/Hydrogen Exchanger.JACC. Basic to translational science · 2026Article
- Association Between Over-the-Counter Magnesium Supplement Use and Health Outcomes in Veterans with Newly Diagnosed Heart Failure.Nutrients · 2025Article
- Dietary predictors of heart failure with preserved ejection fraction among middle-aged adults in the CARDIA study.American heart journal plus : cardiology research and practice · 2025Article
- Association between magnesium oxide use and readmission risk in patients with heart failure and constipation.Journal of pharmaceutical health care and sciences · 2025Article
- Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival.Experimental hematology & oncology · 2025Article
- Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.Scientific reports · 2025Article
- The Role of Hypomagnesemia in Cardiac Arrhythmias: A Clinical Perspective.Biomedicines · 2022Review
- TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt.Communications biology · 2022Article
- Cardiac computed tomography-derived myocardial tissue characterization after anthracycline treatment.ESC heart failure · 2022Article
- A Novel U-Shaped Association Between Serum Magnesium on Admission and 28-Day In-hospital All-Cause Mortality in the Pediatric Intensive Care Unit.Frontiers in nutrition · 2022Article
- HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction.The Korean journal of internal medicine · 2022Article
- Evolving understanding of cardiovascular protection by SGLT2 inhibitors: focus on renal protection, myocardial effects, uric acid, and magnesium balance.Current opinion in pharmacology · 2020Review
- Hospital-Acquired Dysmagnesemia and In-Hospital Mortality.Medical sciences (Basel, Switzerland) · 2020Article
- The controlling nutritional status score predicts outcomes of cardiovascular events in patients with heart failure with preserved ejection fraction.International journal of cardiology. Heart & vasculature · 2020Article
- Clinical relevance of serum ionized magnesium concentration in dogs with myxomatous mitral valve disease.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although serum magnesium (Mg) levels are closely associated with the prognosis of heart failure (HF) patients, the clinical significance of sMg levels on the cardiovascular outcomes of HF with preserved ejection fraction (HFpEF) patients is not fully understood. This study was a retrospective, single-center, observational study. We enrolled 452 consecutive HFpEF patients admitted to Kumamoto University Hospital. We defined lower sMg as <2.0 mg/dl (=0.8 mmol/L) based on recent clinical evidence and compared their clinical characteristics and prognosis. There were no significant differences between groups in the use of all medications (loop diuretics, mineralocorticoid receptor antagonists, renin-angiotensin-aldosterone system inhibitors, calcium channel blockers, beta blockers, statins, and Mg preparations). The lower sMg group showed a significantly higher prevalence of diabetes mellitus (DM), uric acid levels, and BNP levels compared with the higher sMg group. Kaplan-Meier curve revealed a significantly higher probability of HF-related events in the lower sMg group compared with the higher sMg group (log-rank test, P = .012). Multivariate Cox-proportional-hazard analysis revealed that the lower sMg group had significantly and independently higher probabilities of HF-related events compared with the higher sMg group (hazard ratio = 2.37, 95% confidence intervals = 1.27-4.41, P = .007). We reclassified the risk of HF-related events after adding the lower sMg to the other prognostic factors (age, previous hospitalization for HF, DM, Ln-BNP); the continuous net reclassification improvement was 29.0% (P = .041). sMg levels might provide important prognostic information in regard to HFpEF.
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