Evidence map›Paper›PMID 31567892›Full record

ReviewJournal of pediatric gastroenterology and nutrition2019

Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management.

Tom K Lin, Douglas S Fishman, Matthew J Giefer, Quin Y Liu, David Troendle, Steven Werlin, Mark E Lowe, Aliye Uc

Open access · greenAbstract readReview
In one paragraph

Review in Journal of pediatric gastroenterology and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Tom K LinCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Douglas S FishmanBaylor College of Medicine.
Matthew J GieferSeattle Children's Hospital, University of Washington, Seattle, WA.
Quin Y LiuCedars-Sinai Medical Center, Los Angeles, CA.
David TroendleUniversity of Texas Southwestern Medical Center, Dallas, TX.
Steven WerlinMedical College of Wisconsin, Milwaukee, WI.
Mark E LoweWashington University School of Medicine, St. Louis, MO.
Aliye UcStead Family Children's Hospital, University of Iowa, Iowa City, IA.
Cedars-Sinai Medical Center · USCincinnati Children's Hospital Medical Center · USMedical College of Wisconsin · USTexas Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Washington · USWashington University in St. Louis · US

Funding

Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Early Pathogenesis of Cystic Fibrosis Related DiabetesR24DK096518 · NIDDK · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F, MORAN, ANTOINETTE M. · 2012 to 2018
$10.1M
A Randomized Trial of a Web-based Non-Pharmacological Pain Intervention for Pediatric Chronic PancreatitisR01DK118752 · NIDDK · UNIVERSITY OF IOWA · PI PALERMO, TONYA M, UC, ALIYE · 2018 to 2022
$3.0M
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDRENR21DK096327 · NIDDK · UNIVERSITY OF IOWA · PI UC, ALIYE · 2012 to 2014
$586k
NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R01 DK118752NIDDK NIH HHS R21 DK096327NIDDK NIH HHS R24 DK096518NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

objectiveFunctional pancreatic sphincter dysfunction (FPSD), previously characterized as pancreatic sphincter of Oddi dysfunction, is a rarely described cause of pancreatitis. Most studies are reported in adults with alcohol or smoking as confounders, which are uncommon risk factors in children. There are no tests to reliably diagnose FPSD in pediatrics and it is unclear to what degree this disorder contributes to childhood pancreatitis.

methodsWe conducted a literature review of the diagnostic and treatment approaches for FPSD, including unique challenges applicable to pediatrics. We identified best practices in the management of children with suspected FPSD and formed a consensus expert opinion.

resultsIn children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP), we recommend that other risk factors, specifically obstructive factors, be ruled out before considering FPSD as the underlying etiology. In children with ARP/CP, FPSD may be the etiology behind a persistently dilated pancreatic duct in the absence of an alternative obstructive process. Endoscopic retrograde cholangiopancreatography with sphincterotomy should be considered in a select group of children with ARP/CP when FPSD is highly suspected and other etiologies have been effectively ruled out. The family and patient should be thoroughly counseled regarding the risks and advantages of endoscopic intervention. Endoscopic retrograde cholangiopancreatography for suspected FPSD should be considered with caution in children with ARP/CP when pancreatic ductal dilatation is absent.

conclusionsOur consensus expert guidelines provide a uniform approach to the diagnosis and treatment of pediatric FPSD. Further research is necessary to determine the full contribution of FPSD to pediatric pancreatitis.

Indexed as

ChildHumansPancreatitisPractice Guidelines as TopicSphincter of Oddi Dysfunction

Identifiers

PMID31567892
PMCPMC6878194
OpenAlexW2973925809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.