ArticleAnnals of surgery2019
Variation in the Use of Resection for Colorectal Cancer Liver Metastases.
Article in Annals of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Surgical and oncologic outcomes of cT4b rectal cancer: a propensity score-matched comparison between a university center and regional hospitals.Annals of coloproctology · 2026Article
- Trends and Outcomes of the Liver-First Surgical Approach for Patients with Colorectal Cancer and Isolated Liver Metastases.Annals of surgical oncology · 2026Article
- Sex-based differences in survival after liver transplantation for colorectal cancer liver metastases: A multivariable analysis.JHEP reports : innovation in hepatology · 2025Article
- Gender-based variations in surgical management of colorectal liver metastases: comprehensive analysis.BMC cancer · 2025Article
- Risk Factors for Postoperative Complications Following Resection of Colorectal Liver Metastases and the Impact on Long-Term Survival: A Population-Based National Cohort Study.World journal of surgery · 2023Article
- Resectability, Resections, Survival Outcomes, and Quality of Life in Older Adult Patients with Metastatic Colorectal Cancer (the RAXO-Study).Journal of clinical medicine · 2023Article
- Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil.International journal of molecular sciences · 2023Article
- Sex differences in metastatic surgery following diagnosis of synchronous metastatic colorectal cancer.International journal of cancer · 2023Article
- Association of Variation in US County-Level Rates of Liver Surgical Resection for Colorectal Liver Metastasis With Poverty Rates in 2010.JAMA network open · 2023Article
- Changing patterns of multidisciplinary team treatment, early mortality, and survival in colorectal cancer.BJS open · 2022Article
- Hospital factors and metastatic surgery in colorectal cancer patients, a population-based cohort study.BMC cancer · 2022Article
- Surgical Resection of Colorectal Liver Metastases: Attitudes and Practice Patterns in the Deep South.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases.Frontiers in oncology · 2022Article
- Liver-First Approach for Synchronous Colorectal Metastases: Analysis of 7360 Patients from the LiverMetSurvey Registry.Annals of surgical oncology · 2021Article
- Data Resource Profile: The COloRECTal cancer data repository (CORECT-R).International journal of epidemiology · 2021Article
- Liver transplantation in malignant disease.World journal of clinical oncology · 2021Review
- Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients.Cancer medicine · 2021Observational
- National variation in pulmonary metastasectomy for colorectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO): A nationwide prospective intervention study.The Lancet regional health. Europe · 2021Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to investigate variation in the frequency of resections for colorectal cancer liver metastases across the English NHS.
backgroundPrevious research has shown significant variation in access to liver resection surgery across the English NHS. This study uses more recent data to identify whether inequalities in access to liver resection still persist.
methodsAll adults who underwent a major resection for colorectal cancer in an NHS hospital between 2005 and 2012 were identified in the COloRECTal cancer data Repository (CORECT-R). All episodes of care, occurring within 3 years of the initial bowel operation, corresponding to liver resection were identified.
resultDuring the study period 157,383 patients were identified as undergoing major resection for a colorectal tumor, of whom 7423 (4.7%) underwent ≥1 liver resections. The resection rate increased from 4.1% in 2005, reaching a plateau around 5% by 2012. There was significant variation in the rate of liver resection across hospitals (2.1%-12.2%). Patients with synchronous metastases who have their primary colorectal resection in a hospital with an onsite specialist hepatobiliary team were more likely to receive a liver resection (odds ratio 1.22; 95% confidence interval, 1.10-1.35) than those treated in one without. This effect was absent in resection for metachronous metastases.
conclusionsThis study presents the largest reported population-based analysis of liver resection rates in colorectal cancer patients. Significant variation has been observed in patient and hospital characteristics and the likelihood of patients receiving a liver resection, with the data showing that proximity to a liver resection service is as important a factor as deprivation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.