ArticleAlzheimer disease and associated disorders
Retention of Alzheimer Disease Research Participants.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Pre-Randomization Predictors of Study Discontinuation in a Preclinical Alzheimer's Disease Randomized Controlled Trial.The journal of prevention of Alzheimer's disease · 2024Trial
- Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Outreach, Recruitment and Engagement Cores of NIA-designated Alzheimer's Disease Research Centers: Current strategies and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- STELLA-FTD: Examination of a Behavior Change Intervention for Frontotemporal Dementia Family Care Partners.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.BMC research notes · 2026Article
- Experiences of participant burden in an Alzheimer's disease research center longitudinal cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Predictors of Retention in the 1Florida Alzheimer's Disease Research Center (ADRC) Over Two Waves.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core: A culturally informed, community-engaged research (CI-CER) model to advance brain health equity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis.Neurology · 2024Observational
- Retention of American Indian and Alaska Native participants in the National Alzheimer's Coordinating Center Uniform Data Set.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Selection Bias in Health Research: Quantifying, Eliminating, or Exacerbating Health Disparities?Current epidemiology reports · 2024Article
- Brain Health Registry Study Partner Portal: Novel infrastructure for digital, dyadic data collection.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Participant completion of longitudinal assessments in an online cognitive aging registry: The role of medical conditions.Alzheimer's & dementia (New York, N. Y.) · 2024Article
- Estimating attrition in mild-to-moderate Alzheimer's disease and mild cognitive impairment clinical trials.Alzheimer's research & therapy · 2023Article
- Exploratory Correlation of The Human Structural Connectome with Non-MRI Variables in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2023Article
- Recruitment of pre-dementia participants: main enrollment barriers in a longitudinal amyloid-PET study.Alzheimer's research & therapy · 2023Observational
- Mechanisms by Which Cultural-Centric Narrative Influences Interest in ADRD Research Among African American Adults.The Gerontologist · 2023Article
- The Community Engaged Digital Alzheimer's Research (CEDAR) Study: A Digital Intervention to Increase Research Participation of Black American Participants in the Brain Health Registry.The journal of prevention of Alzheimer's disease · 2023Article
- Remote blood collection from older adults in the Brain Health Registry for plasma biomarker and genetic analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
introductionParticipant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.
methodsWe surveyed representative investigators from NIH-funded Alzheimer's Disease Research Centers (ADRC), querying their use of retention tactics across 12 strategies. We compared survey results to data from the National Alzheimer's Coordinating Center for each center. We used a generalized estimating equation with independent working covariance model and empirical standard errors to assess relationships between survey results and rates of retention, controlling for participant characteristics.
resultsTwenty-five (83%) responding ADRCs employed an average 42 (SD=7) retention tactics. In a multivariable model that accounted for participant characteristics, the number of retention tactics used by a center was associated with participant retention (odds ratio=1.68, 95% confidence interval: 1.42, 1.98; P<0.001 for the middle compared with the lowest tertile survey scores; odds ratio=1.59, 95% confidence interval: 1.30, 1.94; P<0.001 for the highest compared with the lowest tertile survey scores) at the first follow-up visit. Participant characteristics such as normal cognition diagnosis, older age, higher education, and Caucasian race were also associated with higher retention.
conclusionsRetention in clinical research is more likely to be achieved by employing a variety of tactics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.