Evidence map›Paper›PMID 31567045›Full record

ArticleHuman vaccines & immunotherapeutics2020

Budget impact analysis of multiple varicella vaccination strategies: a Mexico perspective.

Jonathan Graham, Lara J Wolfson, Jeffrey Kyle, Carlos Perez Bolde-Villarreal, Diana B Guarneros-DeRegil, Homero Monsanto, Matthew Pillsbury, Sandra Talbird, Vincent J Daniels

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jonathan GrahamHealth Economics, Research Triangle Park, RTI Health Solutions, NC, USA.
Lara J WolfsonCenter for Observational and Real World Evidence (CORE), Merck & Co., Inc, Kenilworth, NJ, USA.ORCID 0000-0002-6454-3368
Jeffrey KyleCenter for Observational and Real World Evidence (CORE), Merck & Co., Inc, Kenilworth, NJ, USA.
Carlos Perez Bolde-VillarrealMSD, Mexico Medical Affairs, Mexico.
Diana B Guarneros-DeRegilMSD, Mexico Medical Affairs, Mexico.
Homero MonsantoMSD (IA) LLC, Carolina, Puerto Rico.
Matthew PillsburyCenter for Observational and Real World Evidence (CORE), Merck & Co., Inc, Kenilworth, NJ, USA.
Sandra TalbirdHealth Economics, Research Triangle Park, RTI Health Solutions, NC, USA.ORCID 0000-0003-4719-3703
Vincent J DanielsCenter for Observational and Real World Evidence (CORE), Merck & Co., Inc, Kenilworth, NJ, USA.ORCID 0000-0002-3226-7231
Merck & Co., Inc., Rahway, NJ, USA (United States) · USMSD (Mexico) · MXRTI Health Solutions · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of live-attenuated varicella vaccines are produced globally that provide protection against the varicella zoster virus. In Mexico, varicella vaccination is not included in the national immunization program and is recommended for use only in high-risk subgroups. We developed a budget impact model to estimate the impact of universal childhood immunization against varicella on the national payer system in Mexico. A scenario of no varicella vaccination was compared to scenarios with vaccination with a single dose at 13 months of age, in alignment with the existing program of immunization with the measles-mumps-rubella vaccine. Nine different vaccination scenarios were envisioned, differing by vaccine type and by coverage. Varicella cases and treatment costs of each scenario were computed in a dynamic transmission model of varicella epidemiology, calibrated to the population of Mexico. Unit costs were based on Mexico sources or were from the literature. The results indicated that each of the three vaccine types increased vaccine acquisition and administration expenditures but produced overall cost savings in each of the first 10 years of the program, due to fewer cases and reduced varicella treatment costs. A highly effective vaccine at 95% coverage produced the greatest cost savings.

Indexed as

ChickenpoxChickenpox VaccineChildHumansInfantMeasles-Mumps-Rubella VaccineMexicoVaccinationVaccines, CombinedChickenpox VaccineMeasles-Mumps-Rubella VaccineVaccines, Combinedbudget impact modelchicken poxcostMexicovaccineVaricella zoster virus

Identifiers

PMID31567045
PMCPMC7227656
OpenAlexW2977848612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.