ReviewBrain and behavior2019
Clinical applications of transcranial magnetic stimulation in bipolar disorder.
Review in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Effects of accelerated intermittent θ burst stimulation on depressive episodes and cognitive function in adolescents with bipolar disorder.BMC psychiatry · 2025Trial
- Repetitive transcranial magnetic stimulation: advances for psychiatric disorders.Frontiers in psychiatry · 2026Review
- Alternations of Plasma Fatty Acids in Patients With Bipolar Depression Under Acute Treatment of rTMS Combined With Quetiapine and Mood Stabilizer.Brain and behavior · 2025Article
- Neuromodulation Strategies in Lifelong Bipolar Disorder: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2024Review
- Article
- Article
- Neuroimaging Correlates of Treatment Response to Transcranial Magnetic Stimulation in Bipolar Depression: A Systematic Review.Brain sciences · 2023Review
- Brain stimulation treatment for bipolar disorder.Bipolar disorders · 2023Review
- A Different rTMS Protocol for a Different Type of Depression: 20.000 rTMS Pulses for the Treatment of Bipolar Depression Type II.Journal of clinical medicine · 2022Article
- Devices and Technology in Transcranial Magnetic Stimulation: A Systematic Review.Brain sciences · 2022Review
- State-dependent effects of neural stimulation on brain function and cognition.Nature reviews. Neuroscience · 2022Review
- The Use of Repetitive Transcranial Magnetic Stimulations for the Treatment of Bipolar Disorder: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2022Article
- Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies.Translational psychiatry · 2022Review
- Transdiagnostic Symptom Subtypes to Predict Response to Therapeutic Transcranial Magnetic Stimulation in Major Depressive Disorder and Posttraumatic Stress Disorder.Journal of personalized medicine · 2022Article
- Functional neuroanatomy of mania.Translational psychiatry · 2022Review
- Combination Olanzapine and Samidorphan for the Management of Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review.Health psychology research · 2022Review
- Baseline Clinical and Neuroimaging Biomarkers of Treatment Response to High-Frequency rTMS Over the Left DLPFC for Resistant Depression.Frontiers in psychiatry · 2022Article
- Effect of transcranial magnetic stimulation on treatment effect and immune function.Saudi journal of biological sciences · 2022Article
- Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis.World journal of psychiatry · 2021Article
- Acute and Long Term Treatment of Manic Episodes in Bipolar Disorder.Noro psikiyatri arsivi · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMany patients with bipolar disorder (BD) fail to experience benefit following traditional pharmacotherapy, necessitating alternative treatment options that will enable such patients to achieve remission. Transcranial magnetic stimulation (TMS) is a relatively new, noninvasive neuromodulation technique that involves the application of magnetic pulses on hyperactive or hypoactive cortical brain areas. We evaluated the existing literature on TMS as a treatment for BD across varied mood states.
methodsWe searched PubMed up to October 2018 for original data articles published in English that evaluated outcomes in a bipolar sample across depressive, manic, mixed, and maintenance phases of BD.
resultsClinical trials of TMS for BD particularly suggest the potential of repetitive TMS for reducing depressive symptoms. Studies of TMS for mania have yielded more mixed findings. Few studies have evaluated TMS in other phases of the bipolar illness. TMS is generally associated with mild side effects though, in a few studies, it has been shown to contribute to a manic switch in previously depressed bipolar patients.
conclusionsTranscranial magnetic stimulation is a promising approach for treating patients with BD who have failed to respond to pharmacological or psychosocial treatment. Future research should more clearly elucidate which TMS protocols may be most effective for a given bipolar patient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.