Evidence map›Paper›PMID 31566813›Full record

ArticleJournal of clinical apheresis2019

An updated single center experience with plerixafor and granulocyte colony-stimulating factor for stem cell mobilization in light chain amyloidosis.

Talha Badar, Binod Dhakal, Aniko Szabo, Anand Padmanabhan, Bryon D Johnson, Sarah Heidtke, Jean Esselmann, Saurabh Chhabra, Mehdi Hamadani, Parameswaran Hari and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical apheresis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Talha BadarBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID https://orcid.org/0000-0003-1548-918X
Binod DhakalBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Aniko SzaboInstitute for Health and Equity, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Anand PadmanabhanBlood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin.
Bryon D JohnsonDepartment of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Sarah HeidtkeDepartment of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jean EsselmannBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Saurabh ChhabraBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Mehdi HamadaniBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Parameswaran HariBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.
Anita D'SouzaBMT and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID https://orcid.org/0000-0002-1092-5643
Medical College of Wisconsin · USVersiti Blood Center of Wisconsin · US

Funding

Development and validation of a disease-relevant patient-reported outcome tool in light chain amyloidosisK23HL141445 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI D'SOUZA, ANITA · 2019 to 2022
$597k
NHLBI NIH HHS K23 HL141445
6 · The paper itself

Abstract

The use of granulocyte-colony stimulating factor (G-CSF) with or without chemotherapy to mobilize hematopoietic progenitor cells (HPCs) can result in significant morbidity in light chain (AL) amyloidosis patients. Plerixafor, a strong inducer and mobilizer of HPCs, can be used as an adjunct to G-CSF to improve mobilization efficiency. We describe the outcomes for combined G-CSF/plerixafor mobilized patients with AL amyloidosis. We reviewed data of 53 consecutive AL amyloidosis patients who underwent combined G-CSF/plerixafor HPC mobilization between May 2011 and October 2017 at our institution. We evaluated patients for HPC collection efficiency, perimobilization toxicity and postautologous hematopoietic cell transplantation (autoHCT) outcomes. Median CD34

Indexed as

AdultAntigens, CD34BenzylaminesCyclamsFemaleGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHeterocyclic CompoundsHumansImmunoglobulin Light-chain AmyloidosisMaleMiddle AgedRetrospective StudiesSurvival AnalysisTransplantation, AutologousAntigens, CD34BenzylaminesCyclamsGranulocyte Colony-Stimulating FactorHeterocyclic Compoundsplerixaforamyloidosismobilizationplerixafor

Identifiers

PMID31566813
PMCPMC6957224
OpenAlexW2978317554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.