ArticleeLife2019
Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Establishment of Circadian Rhythm Experiments using Bengalese Finches.The journal of poultry science · 2026Article
- Biochemical characterization of zebrafish Paqr5b.Biochemistry and biophysics reports · 2025Article
- Membrane progesterone receptor γ (paqr5b) is essential for the formation of neurons in the zebrafish olfactory rosette.Scientific reports · 2024Article
- Establishment of a steroid binding assay for goldfish membrane progesterone receptor (mPR) by coupling with graphene quantum dots (GQDs).Fish physiology and biochemistry · 2024Article
- Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation.Cell death and differentiation · 2023Article
- Insights about circadian clock in glioma: From molecular pathways to therapeutic drugs.CNS neuroscience & therapeutics · 2022Review
- Light at Night and Disrupted Circadian Rhythms Alter Physiology and Behavior.Integrative and comparative biology · 2021Review
- Light at night reduces digestive efficiency of developing birds: an experiment with king quail.Die Naturwissenschaften · 2021Article
- Shorebirds' Longer Migratory Distances Are Associated With LargerFrontiers in psychology · 2021Article
- Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells.FASEB bioAdvances · 2020Review
- Pineal Neurosteroids: Biosynthesis and Physiological Functions.Frontiers in endocrinology · 2020Review
- Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats.Frontiers in neuroscience · 2020Article
- The impact of light during the night.eLife · 2019Article
- Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.eLife · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 6 institutions in 1 country.
Funding
Abstract
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.