Evidence map›Paper›PMID 31566567›Full record

ArticleeLife2019

Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats.

Kristina M Wright, Thomas C Jhou, Daniel Pimpinelli, Michael A McDannald

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Serotonin modulates an inhibitory input to the central amygdala from the ventral periaqueductal gray.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  10. Review
  11. Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022
    Review
  12. The Roles of Basolateral Amygdala Parvalbumin Neurons in Fear Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  13. Review
  14. Article
  15. Article
  16. Neural substrates of appetitive and aversive prediction error.Neuroscience and biobehavioral reviews · 2021
    Review
  17. Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kristina M WrightPsychology Department, Boston College, Chestnut Hill, United States.ORCID 0000-0003-1446-3009
Thomas C JhouDepartment of Neuroscience, Medical University of South Carolina, Charleston, United States.ORCID 0000-0001-8811-0156
Daniel PimpinelliPsychology Department, Boston College, Chestnut Hill, United States.
Michael A McDannaldPsychology Department, Boston College, Chestnut Hill, United States.ORCID 0000-0001-8525-1260

Funding

Early life stress, neuron-type function and a raphe-amygdala circuit for threat estimationR01MH117791 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2018 to 2025
$4.0M
Neural encoding of reward and safetyR00DA034010 · NIDA · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2014 to 2016
$727k
NIDA NIH HHS R00 DA034010NIH HHS R00DA034010NIH HHS R01MH117791NIMH NIH HHS R01 MH117791
6 · The paper itself

Abstract

The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue - the presumed neural substrate for fear output - signal threat probability in male rats (Wright et al., 2019). Here, we scrutinize the activity vlPAG neurons that

Indexed as

CuesFearAction PotentialsAnimalsMaleNeuronsPeriaqueductal GrayRatselectrophsyiologyfearmidbrainneuroscienceratthreat

Identifiers

PMID31566567
PMCPMC6821491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.