Evidence map›Paper›PMID 31566436›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis.

Rui Hu, Alicia A McDonough, Anita T Layton

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 72 citations in OpenAlex.

  1. Sex differences in renal acid-base regulation.Current opinion in nephrology and hypertension · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Flow-dependent transport processes 2024: filtration, absorption, and secretion.American journal of physiology. Renal physiology · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rui HuDepartment of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-0459-469X
Anita T LaytonDepartment of Biology and Schools of Computer Science and Pharmacy, University of Waterloo, Waterloo, Ontario, Canada.
University of Waterloo · CAUniversity of Southern California · US

Funding

Sodium transporter regulation during hypertensionR01DK083785 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AURELIE EDWARDS, Alicia A. McDonough · 2011 to 2026
$5.8M
Unraveling Kidney Physiology, Pathophysiology & Therapeutics: A Modeling ApproachR01DK106102 · NIDDK · DUKE UNIVERSITY · PI LAYTON, ANITA · 2016 to 2019
$1.4M
NIDDK NIH HHS R01 DK083785NIDDK NIH HHS R01 DK106102
6 · The paper itself

Abstract

The goal of the present study was to investigate the functional implications of sexual dimorphism in the pattern of transporters along the rodent nephron as reported by Veiras et al. (

Indexed as

AnimalsCarrier ProteinsClaudinsFemaleGlomerular Filtration RateKidney TubulesMaleModels, BiologicalNephronsRatsSex CharacteristicsSodiumSodium ChannelsSodium-Hydrogen ExchangersSodium-Potassium-Chloride SymportersWaterCarrier ProteinsClaudinsCldn2 protein, ratSodiumSodium ChannelsSodium-Hydrogen ExchangersSodium-Potassium-Chloride SymportersWaterepithelial transportsex differences

Identifiers

PMID31566436
PMCPMC7132321
OpenAlexW2978272633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.