ArticleANZ journal of surgery2020
New method in treatment of post-operative air leakage with fresh frozen plasma.
Article in ANZ journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Autologous blood pleurodesis for the treatment of postoperative air leaks. A systematic review and meta-analysis.Thoracic cancer · 2021Pooled it
- Fresh frozen plasma pleurodesis for bronchopleural fistula following secondary spontaneous pneumothorax due to ruptured emphysematous bullae in a high-risk elderly COPD patient.Respiratory medicine case reports · 2026Article
- Advancements in the Management of Postoperative Air Leak following Thoracic Surgery: From Traditional Practices to Innovative Therapies.Medicina (Kaunas, Lithuania) · 2024Review
- Intraoperative prevention and conservative management of postoperative prolonged air leak after lung resection: a systematic review.Journal of thoracic disease · 2023Review
- Treatment of postoperative air leak with fresh frozen plasma.Journal of thoracic disease · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo consensus regarding the best post-operative treatment option for air leak has been established. In this study, we evaluate the use of intra-pleural fresh frozen plasma (FFP) as a promising treatment method.
methodsTreatment for a sustained air leak (3 days) was warranted in approximately 12% of the lung surgeries at our institution. Fifty-two patients were treated with FFP by application of 250 mL daily. The patients were divided into two cohorts: cohort 1 consisted of 35 patients undergoing anatomical lung resections and cohort 2 consisted of 17 patients after miscellaneous types of lung surgery. Successfulness of the procedure as well as the potential influential factors was evaluated statistically and validated by a bootstrapping. Area under receiver operating characteristic curve was used to establish a cut-off value of the predictor.
resultsIn the first cohort, air leakage was successfully treated in 28 (80%), while in seven (20%) it was still present after third treatment with FFP. The success rate in cohort 2 was 76.5%. The only covariate which appeared to remain significant in both cohorts was flow as displayed on the digital suction device prior to application of FFP. Flow ≤375 mL/min was indicative of successful aerostasis.
conclusionIntra-pleural instillation of FFP seems to be a feasible method for the treatment of post-operative air leakage. Although the optimum strategy regarding its application as well as its limitations is yet to be established, an absence of complications or undesirable events makes this (off label) method a safe and promising alternative to existing options.
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