Evidence map›Paper›PMID 31566262›Full record

ArticleMagnetic resonance in medicine2020

Optimal acquisition scheme for flow-compensated intravoxel incoherent motion diffusion-weighted imaging in the abdomen: An accurate and precise clinically feasible protocol.

Oliver J Gurney-Champion, Susanne S Rauh, Kevin Harrington, Uwe Oelfke, Frederik B Laun, Andreas Wetscherek

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  10. Diffusion-weighted Imaging of the Abdomen during a Single Breath-hold Using Simultaneous-multislice Echo-planar Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023
    Article
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  13. Characterisation of microvessel blood velocity and segment length in the brain using multi-diffusion-time diffusion-weighted MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oliver J Gurney-ChampionJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.ORCID 0000-0003-1750-6617
Susanne S RauhJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Kevin HarringtonTargeted Therapy team, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Uwe OelfkeJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.
Frederik B LaunInstitute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Andreas WetscherekJoint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom.

Funding

Cancer Research UK 19727Cancer Research UK 21993Cancer Research UK 28284Cancer Research UK C33589/A19727Cancer Research UK C7224/A23275Medical Research Council MC_EX_MR/M009068/1Medical Research Council MR/M009068/1
6 · The paper itself

Abstract

purposeFlow-compensated (FC) diffusion-weighted MRI (DWI) for intravoxel-incoherent motion (IVIM) modeling allows for a more detailed description of tissue microvasculature than conventional IVIM. The long acquisition time of current FC-IVIM protocols, however, has prohibited clinical application. Therefore, we developed an optimized abdominal FC-IVIM acquisition with a clinically feasible scan time.

methodsPrecision and accuracy of the FC-IVIM parameters were assessed by fitting the FC-IVIM model to signal decay curves, simulated for different acquisition schemes. Diffusion-weighted acquisitions were added subsequently to the protocol, where we chose the combination of b-value, diffusion time and gradient profile (FC or bipolar) that resulted in the largest improvement to its accuracy and precision. The resulting two optimized FC-IVIM protocols with 25 and 50 acquisitions (FC-IVIM

resultsSimulations showed that the performance of FC-IVIM improved in tissue with larger perfusion fraction and signal-to-noise ratio. The scan time of the FC-IVIM

conclusionsWe have optimized the FC-IVIM protocol, allowing for clinically feasible scan times (8-16 min).

Indexed as

Diffusion Magnetic Resonance ImagingMotionAbdomenAdultAlgorithmsComputer SimulationFemaleHealthy VolunteersHumansKidneyLiverMaleModels, StatisticalPerfusionReproducibility of ResultsRespirationDiffusion-weighted MRIintravoxel incoherent motionperfusionquantitative MRI

Identifiers

PMID31566262
PMCPMC6899942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.