Evidence map›Paper›PMID 31566069›Full record

ArticleRNA biology2020

Developmental changes of rRNA ribose methylations in the mouse.

Jade Hebras, Nicolai Krogh, Virginie Marty, Henrik Nielsen, Jérôme Cavaillé

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
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  8. Article
  9. Impacts of ribosomal RNA sequence variation on gene expression and phenotype.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  10. Ribosomes: from conserved origin to functional/medical mobility and heterogeneity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. The zebrafish (NAR genomics and bioinformatics · 2025
    Article
  12. Ribosome Structural Changes Dynamically Affect Ribosome Function.International journal of molecular sciences · 2024
    Review
  13. Article
  14. 2'-RNA (New York, N.Y.) · 2024
    Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jade HebrasLaboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
Nicolai KroghDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8870-7091
Virginie MartyLaboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
Henrik NielsenDepartment of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7143-2810
Jérôme CavailléLaboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
Centre National de la Recherche Scientifique · FRUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sequencing-based profiling method (RiboMeth-seq) for ribose methylations was used to study methylation patterns in mouse adult tissues and during development. In contrast to previous reports based on studies of human cancer cell lines, almost all methylation sites were close to fully methylated in adult tissues. A subset of sites was differentially modified in developing tissues compared to their adult counterparts and showed clear developmental dynamics. This provides the first evidence for ribosome heterogeneity at the level of rRNA modifications during mouse development. In a prominent example, the expression levels of SNORD78 during development appeared to be regulated by alternative splicing of the

Indexed as

Gene Expression Regulation, DevelopmentalAlternative SplicingAnimalsComputational BiologyEmbryonic DevelopmentGene Expression ProfilingIntronsMethylationMiceOrgan SpecificityRiboseRNA, RibosomalRiboseRNA, Ribosomalalternative splicingGas5mouse developmentRibose methylationrRNASNORD78specialized ribosomes

Identifiers

PMID31566069
PMCPMC6948968
OpenAlexW2978135423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.