Evidence map›Paper›PMID 31566057›Full record

ArticleJournal of child neurology2020

Clinical Features and Outcomes of Pediatric Monophasic and Recurrent Idiopathic Optic Neuritis.

Soren Jonzzon, Leena Suleiman, Andrew Yousef, Brenda Young, Janace Hart, Patrick Peschl, Markus Reindl, Kristin L Schaller, Jeffrey L Bennett, Emmanuelle Waubant and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children.Annals of clinical and translational neurology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Soren JonzzonMedical School of the University of California, San Francisco, CA, USA.ORCID 0000-0002-6857-1569
Leena SuleimanMedical School of the University of California, San Francisco, CA, USA.
Andrew YousefMedical School of the University of California, San Francisco, CA, USA.
Brenda YoungDepartment of Neurology, University of California, San Francisco, CA, USA.
Janace HartDepartment of Neurology, University of California, San Francisco, CA, USA.
Patrick PeschlClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Markus ReindlClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Kristin L SchallerDepartment of Neurology, Program in Neuroscience, University of Colorado School of Medicine, Aurora, CO, USA.
Jeffrey L BennettDepartment of Ophthalmology, Program in Neuroscience, University of Colorado School of Medicine, Aurora, CO, USA.
Emmanuelle WaubantDepartment of Neurology, University of California, San Francisco, CA, USA.
Jennifer S GravesDepartment of Neurology, University of California, San Francisco, CA, USA.
University of California, San Francisco · USInnsbruck Medical University · ATUniversity of Colorado Denver · US

Funding

Humoral Immunity, Astrocyte Injury, and Demyelination in Neuromyelitis OpticaR01EY022936 · NEI · UNIVERSITY OF COLORADO DENVER · PI BENNETT, JEFFREY L · 2013 to 2022
$3.8M
NEI NIH HHS R01 EY022936
6 · The paper itself

Abstract

Limited data exist on isolated optic neuritis in children. We report the clinical features and treatment of pediatric subjects with monophasic and recurrent idiopathic optic neuritis. This retrospective cohort study of patients with isolated optic neuritis identified 10 monophasic and 7 recurrent optic neuritis cases. Monophasic optic neuritis patients were older (mean 13.3 ± 4.22) than those with recurrent idiopathic optic neuritis (9.86 ± 3.63). Females represented 50% of monophasic and 85.7% of recurrent idiopathic optic neuritis cases. Patients with monophasic optic neuritis were less likely to have a bilateral onset than recurrent idiopathic optic neuritis (40% vs 57.1%). Only 1 case had oligoclonal bands in the cerebrospinal fluid CSF. Most recurrent idiopathic optic neuritis cases had evidence of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (5/7). Treatment of recurrent idiopathic optic neuritis cases included intravenous pulse glucocorticosteroids and immunotherapy. We observed differences between recurrent and monophasic idiopathic optic neuritis. Immunosuppression appeared to prevent further relapses in recurrent idiopathic optic neuritis patients. Weaning immunotherapies after several years of quiescence in recurrent idiopathic optic neuritis may be possible, but larger studies are needed.

Indexed as

AutoantibodiesAdolescentChildFemaleGlucocorticoidsHumansImmunotherapyMaleMyelin-Oligodendrocyte GlycoproteinOptic NeuritisRecurrenceRetrospective StudiesAutoantibodiesGlucocorticoidsMyelin-Oligodendrocyte Glycoproteinadolescentschildrenepidemiologyneuroimmunologyneuroophthalmologypediatrictreatment

Identifiers

PMID31566057
PMCPMC7018758
OpenAlexW2978377411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.