Evidence map›Paper›PMID 31565893›Full record

ArticleJournal of veterinary science2019

Regulation of porcine endogenous retrovirus by dual LTR1+2 (Long Terminal Region) miRNA in primary porcine kidney cells.

Hee Chun Chung, Van Giap Nguyen, Hyung Joon Moon, Yong Ho Park, Bong Kyun Park

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hee Chun ChungDepartment of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.ORCID https://orcid.org/0000-0003-4666-5393
Van Giap NguyenDepartment of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.ORCID https://orcid.org/0000-0001-5250-1825
Hyung Joon MoonResearch Unit, Green Cross Veterinary Products, Yongin 17066, Korea.ORCID https://orcid.org/0000-0001-6211-8758
Yong Ho ParkDepartment of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea. yhp@snu.ac.kr.ORCID https://orcid.org/0000-0002-4168-6884
Bong Kyun ParkDepartment of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea. parkx026@snu.ac.kr.ORCID https://orcid.org/0000-0002-4301-8740
Seoul National University · KRGreen Cross (South Korea) · KRVietnam National University of Agriculture · VN

Funding

Ministry of Agriculture, Food and Rural Affairs 1150043Ministry of Agriculture, Food and Rural Affairs Z-1543081-2016-17-01Rural Development Administration PJ011184
6 · The paper itself

Abstract

Porcine endogenous retroviruses (PERVs) integrate into germline DNA as proviral genome that enables vertical transmission from parents to their offspring. The provirus usually survives as part of the host genome rather than as an infectious agent, but may become pathogenic if it crosses species barriers. Therefore, replication-competent PERV should be controlled through selective breeding or knockout technologies. Two microRNAs (miRNAs), dual LTR1 and LTR2, were selected to inhibit the expression of PERV in primary porcine kidney cells. The inhibition efficiency of the miRNAs was compared based on their inhibition of different PERV regions, specifically long terminal repeats (

Indexed as

AnimalsCell LineEndogenous RetrovirusesKidneyMicroRNAsRetroviridae InfectionsSwineSwine DiseasesTerminal Repeat SequencesMicroRNAsinhibitionlong terminal regionmiRNAPorcine endogenous retrovirusprimary porcine kidney cell

Identifiers

PMID31565893
PMCPMC6769330
OpenAlexW2971027189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.