Evidence map›Paper›PMID 31565818›Full record

ArticleMagnetic resonance in medicine2020

Acute enhancement of necrotic radio-frequency ablation lesions in left atrium and pulmonary vein ostia in swine model with non-contrast-enhanced T

Michael A Guttman, Susumu Tao, Sarah Fink, Rick Tunin, Ehud J Schmidt, Daniel A Herzka, Henry R Halperin, Aravindan Kolandaivelu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Interventional cardiovascular magnetic resonance: state-of-the-art.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Black-Blood Contrast in Cardiovascular MRI.Journal of magnetic resonance imaging : JMRI · 2022
    Review
  12. Article
  13. Native contrast visualization and tissue characterization of myocardial radiofrequency ablation and acetic acid chemoablation lesions at 0.55 T.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael A GuttmanDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0001-9296-4170
Susumu TaoDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Sarah FinkDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Rick TuninDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Ehud J SchmidtDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Daniel A HerzkaCardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Henry R HalperinDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Aravindan KolandaiveluDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USNational Institutes of Health · US

Funding

Improved Targeting and Assessment of Electrophysiology InterventionR01HL094610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2009 to 2018
$15.5M
Intraprocedure Model-Guided ElectrophysiologyR01EB022011 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2018 to 2021
$2.3M
NHLBI NIH HHS R01 HL094610NIBIB NIH HHS R01 EB022011
6 · The paper itself

Abstract

purposeTo evaluate non-contrast-enhanced MRI of acute radio-frequency ablation (RFA) lesions in the left atrium (LA) and pulmonary vein (PV) ostia. The goal is to provide a method for discrimination between necrotic (permanent) lesions and reversible injury, which is associated with recurrence after treatment of atrial fibrillation.

methodsFifteen normal swine underwent RFA around the right-superior PV ostia. Electrical pulmonary vein isolation (PVI) was verified by electro-anatomic mapping (EAM) and pacing. MRI was carried out using a 3D respiratory-gated T

resultsRFA lesions exhibited unambiguous enhancement in acute TWILITE imaging (IIR = 2.34 ± 0.49 at 1.5T), and the enhancement patterns corresponded well with gross pathology. Lesion widths in MRI correlated well with gross pathology (R

conclusionTWILITE imaging allowed acute detection of permanent RFA lesions in swine LA and PV ostia, without the need for contrast agent. Lesion enhancement pattern showed good correspondence to gross pathology and was well visualized by volume rendering. This method may provide valuable intra- or post-procedural assessment of RFA treatment.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsRadiofrequency AblationAnimalsHeart AtriaMagnetic Resonance ImagingSwineatrial arrhythmialeft atriumlesion gapsmagnetic resonance imagingnon-contrast-enhancedpulmonary vein isolationrecurrenceT1-weighted radiofrequency ablation

Identifiers

PMID31565818
PMCPMC6949368
OpenAlexW2978880456

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.