ArticleEuropean journal of applied physiology2019
Acute glutamine supplementation does not improve 20-km self-paced cycling performance in the heat.
Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Sports Dietitians Australia and Ultra Sports Science Foundation Joint Position Statement: A Practitioner Guide to the Prevention and Management of Exercise-Associated Gastrointestinal Perturbations and Symptoms.Sports medicine (Auckland, N.Z.) · 2025Guideline
- The Influence of Dietary Supplements on Exercise-Induced Gut Damage and Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- A systematic review: Role of dietary supplements on markers of exercise-associated gut damage and permeability.PloS one · 2022Pooled it
- Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men.European journal of nutrition · 2022Trial
- Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study.Nutrients · 2020Trial
- Glutamine Supplementation and Exercise: A Narrative Review of Biochemical Mechanisms and Timing Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Gastrointestinal function and microbiota in endurance athletes.Frontiers in physiology · 2025Review
- Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat-Related Illness.Journal of nutrition and metabolism · 2024Review
- Acute heat stress-indued apoptosis in mouse skeletal muscle is not associated with alteration of glutamine homeostasis.PloS one · 2022Article
- No protective benefits of low dose acute L-glutamine supplementation on small intestinal permeability, epithelial injury and bacterial translocation biomarkers in response to subclinical exertional-heat stress: A randomized cross-over trial.Temperature (Austin, Tex.) · 2022Article
- Short-term heat acclimation preserves knee extensor torque but does not improve 20 km self-paced cycling performance in the heat.European journal of applied physiology · 2021Article
- The Gastrointestinal Exertional Heat Stroke Paradigm: Pathophysiology, Assessment, Severity, Aetiology and Nutritional Countermeasures.Nutrients · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe premise of this study was to investigate the effect of acute glutamine supplementation on 20 km time trial cycling performance in the heat, neuromuscular function, inflammation and endotoxemia.
methodsTwelve cyclists completed two, 20-km time trials (20TT) in 35 °C (50% relative humidity). Participants ingested either glutamine (GLUT; 0.9 g kg
results20TT in the heat increased I-FABP and elevated inflammatory cytokines (IL-6 and TNF-α) compared to pre-exercise values but did not result in endotoxemia. Completion time was not statistically different between conditions (mean difference [95% credible interval] = 11 s [- 23, 44]). Relative to CON, GLUT did not alter any physiological or perceptual measures during the 20TT.
conclusionGlutamine supplementation does not improve 20TT performance in the heat or preserve neuromuscular function when compared to a placebo. These findings suggest that glutamine is not an ergogenic aid or prophylactic intervention for heat-induced gut damage during short-duration self-paced exercise in hot environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.