ArticleJournal of experimental botany2020
Chemically induced herbicide tolerance in rice by the safener metcamifen is associated with a phased stress response.
Article in Journal of experimental botany, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Deciphering Pesticide Stress Responses in Rice Through Integrated Multi-Omic Assessment.Toxics · 2026Review
- Article
- Transcriptomic analysis reveals cloquintocet-mexyl-inducible genes in hexaploid wheat (Triticum aestivum L.).PloS one · 2025Article
- Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 againstMolecules (Basel, Switzerland) · 2024Article
- Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen Infection.Plant & cell physiology · 2024Article
- Transcriptionally linked simultaneous overexpression of P450 genes for broad-spectrum herbicide resistance.Plant physiology · 2023Article
- Selective herbicide safening in dicot plants: a case study inFrontiers in plant science · 2023Article
- Role of Antioxidant Enzymes and Glutathione S-Transferase in Bromoxynil Herbicide Stress Tolerance in Wheat Plants.Plants (Basel, Switzerland) · 2022Article
- Characterization of Cytochrome P450s with Key Roles in Determining Herbicide Selectivity in Maize.ACS omega · 2022Article
- Article
- Development of novel pesticides in the 21st century.Journal of pesticide science · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The closely related sulphonamide safeners, metcamifen and cyprosulfamide, were tested for their ability to protect rice from clodinafop-propargyl, a herbicide normally used in wheat. While demonstrating that both compounds were equally bioavailable in planta, only metcamifen prevented clodinafop from damaging seedlings, and this was associated with the enhanced detoxification of the herbicide. Transcriptome studies in rice cultures demonstrated that whereas cyprosulfamide had a negligible effect on gene expression over a 4 h exposure, metcamifen perturbed the abundance of 590 transcripts. Changes in gene expression with metcamifen could be divided into three phases, corresponding to inductions occurring over 30 min, 1.5 h and 4 h. The first phase of gene induction was dominated by transcription factors and proteins of unknown function, the second by genes involved in herbicide detoxification, while the third was linked to cellular homeostasis. Analysis of the inducible genes suggested that safening elicited similar gene families to those associated with specific biotic and abiotic stresses, notably those elicited by abscisic acid, salicylic acid, and methyl jasmonate. Subsequent experiments with safener biomarker genes induced in phase 1 and 2 in rice cell cultures provided further evidence of similarities in signalling processes elicited by metcamifen and salicylic acid.
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