Evidence map›Paper›PMID 31565742›Full record

ArticleAmerican journal of epidemiology2019

Longitudinal Changes in the Genital Hiatus Preceding the Development of Pelvic Organ Prolapse.

Victoria L Handa, Joan L Blomquist, Megan Carroll, Jennifer Roem, Alvaro Muñoz

Abstract read
In one paragraph

Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026
    Review
  7. Pelvic shape predisposes for pelvic organ prolapse: a geometric morphometry study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Surgical Repair of the Genital Hiatus: A Narrative Review.International urogynecology journal · 2021
    Review
  19. Article
  20. The role of the genital hiatus and prolapse symptom bother.International urogynecology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Victoria L HandaDepartment of Gynecology and Obstetrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Joan L BlomquistGreater Baltimore Medical Center, Baltimore, Maryland.
Megan CarrollDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Jennifer RoemDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Alvaro MuñozDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Funding

Cesarean and vaginal birth: cohort study of the impact on pelvic floor disordersR01HD056275 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HANDA, VICTORIA LYNN · 2008 to 2017
$5.7M
Mechanisms for pelvic organ prolapse after obstetrical levator muscle injuryR01HD082070 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HANDA, VICTORIA LYNN · 2015 to 2017
$992k
NICHD NIH HHS R01 HD056275NICHD NIH HHS R01 HD082070
6 · The paper itself

Abstract

We aimed to explore relationships between changes in genital hiatus (GH) and development of pelvic organ prolapse using data from the Mothers' Outcomes After Delivery (MOAD) Study, a Baltimore, Maryland, cohort study of parous women who underwent annual assessments during 2008-2018. Prolapse was defined as any vaginal segment protrusion beyond the hymen or reported prolapse surgery. For each case, 5 controls (matched on birth type and interval from first delivery to study enrollment) were selected using incidence sampling methods. We used a mixed model whose fixed effects described the initial size and slope of the GH as a function of prolapse status (case vs. control) and with nested (women within matched sets) random effects. Among 1,198 women followed for 1.0-7.3 years, 153 (13%) developed prolapse; 754 controls were matched to those women, yielding 3,664 visits for analysis. GH was 20% larger among the cases at enrollment (3.16 cm in cases vs. 2.62 cm in controls; P < 0.001), and the mean rate of increase in the size of the GH was more than 3 times greater (0.56 cm per 5-year period vs. 0.15 cm per 5-year period in controls; P < 0.001). Thus, to identify women at highest risk for developing prolapse, health-care providers could evaluate not simply the size of the GH but also changes in the GH over time.

Indexed as

AdultCase-Control StudiesFemaleHumansLongitudinal StudiesPelvic Organ ProlapseVaginaempirical Bayes methodsgenital hiatusmixed-effects modelsnested case-control studiespelvic organ prolapse

Identifiers

PMID31565742
PMCPMC7036657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.